Hydrogels biocompatibility

Investigations on biocompatible hydrogels based exclusively on polysaccharide chains were reported chitosan was linked with dialdehyde obtained from scleroglucan by controlled periodate oxidation [218]. The reaction took... 

Yang CY, Song BB, Ao Y et al (2009) Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system. Biomaterials 30 2881-2898... 

The equilibrium swelling degree is the most important property of a hydrogel it directly influences the rate of water sorption, the permeability to drugs, and the mechanical strength of the gel. It also affects the biocompatibility of the... 

Song, J., Saiz, E. and Bertozzi, C.R. (2003) A new approach to mineralization of biocompatible hydrogel scaffolds an efficient process toward 3-dimensional bonelike composites. Journal of the American Chemical Society, 125, 1236-1243. 

Schiraldi et al. [64] have developed this kind of material by combining silica particles and pHEMA. pHEMA is a biocompatible hydrogel that has been widely studied in the past decades due to its chemical-physical structure and mechanical properties. It has been widely used in ophthalmic prostheses (contact or intraocular lenses), vascular prostheses, drug delivery systems and soft-tissue replacement [65]. These authors have shown that by incorporating silica nanoparticles, the resulting hybrid material is highly biocompatible and promotes bone cell adhesion and proliferation of bone cells seeded on it.1 ... 

Similarly to the phospholipid polymers, the MPC polymers show excellent biocompatibility and blood compatibility [43—48]. These properties are based on the bioinert character of the MPC polymers, i.e., inhibition of specific interaction with biomolecules [49, 50]. Recently, the MPC polymers have been applied to various medical and pharmaceutical applications [44-47, 51-55]. The crosslinked MPC polymers provide good hydrogels and they have been used in the manufacture of soft contact lenses. We have applied the MPC polymer hydrogel as a cell-encapsulation matrix due to its excellent cytocompatibility. At the same time, to prepare a spontaneously forming reversible hydrogel, we focused on the reversible covalent bonding formed between phenylboronic acid and polyol in an aqueous system. 

Choi J, Konno T, Matsuno R et al (2008) Surface immobilization of biocompatible phospholipid polymer multilayered hydrogel on titanium alloy. Colloids Surf B Biointerfaces 67 216-223... 

Also, PVA hydrogels evidenced a very good behaviour in contact with skin and other tissues, mucosa, or blood. PVA exhibits a bioadhesive nature, shape-memory properties, avoid the protein adsorption onto the gel surface and is biocompatible. 

One can conclude that PVA hydrogels represent an efficient encapsulation vehicle for the studied porphyrins, both water soluble and non-water soluble. Their biocompatible, biodegradable, non-toxic, and non-carcinogenic nature makes them especially effective for pharmaceutical applications, but also for environmental uses, such as advanced wastewater... 

Ratner, B. Biomedical applications of hydrogels Critical appraisal and review, in D. F. Williams, Ed. Biocompatibility of Clinical Implant Materials, pp. 145-153. CRC Press, Boca Raton, FL, 1981. 

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