Hydrocortisone Theophylline

Other Formulations. Neural networks have been applied to the modeling of pellet formulations to control the release of theophylline [63] and to control the rate of degradation of omeprazole [64]. They have also been applied to the preparation of acrylic microspheres [65] and to model the release of insulin from an implant [66]. In arecent study from Brazil, the release of hydrocortisone from a biodegradable matrix has been successfully modeled [67]. 

Hydrocortisone Digoxin Theophyllin Solid-state peroxyoxalate CL, high-performance liquid chromatography 2 ng/mL 2 ng/mL 4 ng/mL 74... 

Figure 6.17 The classification of 42 drugs in the (solubility-dose ratio, apparent permeability) plane of the QBCS. The intersection of the dashed lines drawn at the cutoff points form the region of the borderline drugs. Key 1 acetyl salicylic acid 2 atenolol 3 caffeine 4 carbamazepine 5 chlorpheniramine 6 chlorothiazide 7 cimetidine 8 clonidine 9 corticosterone 10 desipramine 11 dexamethasone 12 diazepam 13 digoxin 14 diltiazem 15 disopyramide 16 furosemide 17 gancidovir 18 glycine 19 grizeofulvin 20 hydrochlorothiazide 21 hydrocortisone 22 ibuprofen 23 indomethacine 24 ketoprofen 25 mannitol 26 metoprolol 27 naproxen 28 panadiplon 29 phenytoin 30 piroxicam 31 propanolol 32 quinidine 33 ranitidine 34 salicylic acid 35 saquinavir 36 scopolamine 37 sulfasalazine 38 sulpiride 39 testosterone 40 theophylline 41 verapamil HC1 42 zidovudine.

It is important to realize that a discussion of solvent polarity is only useful when considered in relation to a particular solute. Thus, for a semipolar solute such as theophylline, pure ethanol might be considered nonpolar, but for a relatively non-polar solute such as hydrocortisone, ethanol might be considered semipolar. This concept is illustrated in Fig. 1. For nonpolar and polar solutes, solubility will continually decrease or increase, respectively, as solvent polarity increases. For semipolar solutes, solubility reaches a maximum at some intermediate solvent polarity. It should be noted that the reverse argument (i.e., solute polarity should be discussed relative to solvent polarity) is also valid. 

Noninterfering amoxicillin, ceiffeine, dexamethasone, gentamicin, hydrocortisone, indo-methacin, metoclopramide, midazolam, theobromine, theophylline, tolazoline... 

Noninterfering acetaminophen, aspirin, hydrocortisone, phenylbutazone, prednisolone, saliQrlic acid, terbutahne, theophylline... 

Extracted carbamazepine, ethosuximide, phenobarbital, primidone Simultaneous amobarbital, barbital, chlordiazepoxide, codeine, ethotoin, glutethimide, hexobarbital, hydrocortisone, mephenytoin, mephobarbital, metharbital, methsuximide, nitrazepam, phenacetin, phensixximide, secobarbital Noninterfering acetaminophen, acetazolamide, amphetamine, bilirubin, caffeine, diazepam, dimenhydrinate, meperidine, meprobamate, methamphetamine, methaqualone, methylphenidate, nicotine, propoxyphene, theophylline, valproic acid Interfering pentobarbital... 

Simultaneous acetaminophen, aldosterone, allopurinol, amitriplyline, caffeine, calcitriol, cephalothin, chlordiazepoxide, chlorothiazide, corticosterone, cortisone, dexamethasone, diazepam, ephedrine, ethinyl estradiol, furosemide, hydrocortisone, ibuprofen, imipra-mine, indomethacin, mechlorethamine, methylprednisone, metolazone, nandrolone, naproxen, phenacetin, phenobarbital, phen3doin, probenecid, progesterone, propranolol, sulfasalazine, testosterone, theophylline, vincristine... 

Buchanan N, Hurwitz S, Butler P. Asthma—a possible interaction between hydrocortisone and theophylline. S Afr Med J ( 9T9) 56, 1147-8. 

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