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Hydro-hydroxy-addition

Hydration of Double bonds Hydro-hydroxy-addition... [Pg.1032]

The Addition of Water to Aldehydes and Ketones. Formation of Hydrates O-Hydro-C-hydroxy-addition... [Pg.882]

Interposition of a methylene group between the phenyl ring and the heterocycle leads to the benzyldiami nopyrimidines, a class of compounds notable for their antibacterial activity. Condensation of hydrocinnamate 54 with ethyl formate leads to the hydroxymethylene derivative 55. In this case, too, the heterocyclic ring is formed by reaction with guanidine. This sequence probably involves initial addition-elimination to the formyl carbon to form 56 cyclization in this case involves simple amide formation. Tautomerization then affords the hydroxy derivative 57. This is converted to tetroxoprim (58) by first replacing the hydro) l by chlorine and then- displacement of halogen with ammonia. [Pg.1203]

The plausible mechanism of the reaction is shown in Fig. 25. The reaction probably proceeds through the activation of imine (formed in situ from the o-hydroxy benzaldehyde and the aromatic amine) by the catalyst followed by the addition and subsequent cyclization of the enol ether, resulting in the formation of the fused acetal. Ionic liquids are stable enough with amines and water and also effectively activate the imines to undergo cyclization. The recovered ionic liquid can be re-used with gradual decrease in the efficiency of the method. The hydro-phobic nature of the ionic liquid also helps in recovery of the catalyst. [Pg.249]

Oxidation of thiophene with peracid under carefully controlled conditions gives a mixture of thiophene 1-oxide and 2-hydroxy thiophene 1-oxide (48) (for a recent review on thiophene 1-oxide see (97SR(19)349)). These compounds are trapped by addition to benzoquinone to give ultimately naphthoquinone (47) and its 5-hydro derivative (49) (71ACS(B)353). Diels-Alder reaction also gives (50). [Pg.302]

Further discussion and additional references to the synthesis of peptides containing dide-hydro-a-amino acids, reduced peptide isosteres, TV-hydroxy amides and hydrazides, and Ca-tetrasubstituted amino acids including 2,3-methano amino acids can be found in Sections 11.1,10.7,10.8, and 10.3, respectively. [Pg.744]

The pAf-value for the hydro xycyclohexadienyl radical formed by addition of OH to an aromatic ring is above 14, similar to /3-hydroxy-alkyl radicals as might be expected from the electron distribution. [Pg.257]

When 4-hydroxy benzoic acid was used in place of phenol, most of the 4-hydro-xybenzoic add derivatives crystallised out on addition of the crude reaction mixture to water, the remainder being removed by base extraction of the filtrate. [Pg.488]

Ar — CH = N — OH + R2B-CH2-CH = CH-CH3) Cyclopentan 2-Anilino-l-hydroxy-E16d, 1124 (Addition/Hydro-lyse)... [Pg.903]

A in Fig. 13.25). This is the reaction formally catalyzed by EC 2.3.1.118 with acetyl-CoA acting as the acetyl donor the JV-hydroxy metabolites of a number of arylamines are known substrates. The same conjugates can be formed by intramolecular AT,0-acetyl transfer, when an arylhydroxamic acid (an AT-aiyl-JV-hydro y-acetamide) is substrate of, e.g., EC 2.3.1.56 (reaction 3-B). In addition, such an arylhydroxamic acid can transfer its acetyl moiety to an acetyltransferase, which can then acetylate an... [Pg.457]

Irradiation of aqueous solutions of 5-methylphenazinium salts yields the 10-hydro cation radical and the 1-hydroxy-derivative (101) in a stoicheiometric 2 I ratio. An e.s.r. study suggests that free hydroxyl radicals are not likely to be involved in the reaction. A more extensive study shows that addition of water... [Pg.361]

In addition to decarboxylation, the oxidation of acids yields hydro-peroxy, hydroxy, keto groups, lactones, and mono- and dicarboxylic acids of lower molecular weight. The mechanism of the oxidation of acids is similar to that for hydrocarbons. The reactivity of mono- [300] and dicarboxylic acids [216] with respect to cumylperoxy radicals was measured by oxidation in the presence of cumyl hydroperoxide as source of R02 (see Table 15). The reactivities of methylenic groups in mono- and dicarboxylic acids and in rc-paraffin acids are close. For example, at 100° C, feCH2 X 102 (1 mole-1 s-1) = 4.8 (n-decane), 10.0 (glutaric, sebacic, j3,7 groups), 6.4 (a-CH2 of dibasic acids), 8.0 (for monocarboxylic acids), and 11.0 (>CH2 for propionic acid). [Pg.175]

In 2006 Palomo and coworkers tested several prolinamides in the asymmetric Michael addition of aliphatic aldehydes to nitroalkenes. Hydroxy-proline-derived amides 13 were found to be the most active catalysts for this transformation, establishing the importance of the hydrojy group not only for reaction stereocontrol, but also for catalyst activity. However, 3-hydro>y-prolinamide 13b gave less satisfactory results in terms of stereocontrol, compared to the 4-hydro>y-prolinamide analogue 13a (Scheme 11.11). [Pg.269]


See other pages where Hydro-hydroxy-addition is mentioned: [Pg.993]    [Pg.759]    [Pg.993]    [Pg.759]    [Pg.1175]    [Pg.1262]    [Pg.248]    [Pg.163]    [Pg.92]    [Pg.280]    [Pg.164]    [Pg.921]    [Pg.133]    [Pg.380]    [Pg.2018]    [Pg.524]    [Pg.25]    [Pg.609]    [Pg.830]    [Pg.1481]    [Pg.192]    [Pg.67]    [Pg.716]    [Pg.375]    [Pg.1102]    [Pg.173]    [Pg.364]    [Pg.27]    [Pg.276]    [Pg.696]    [Pg.18]    [Pg.453]    [Pg.461]    [Pg.16]    [Pg.168]    [Pg.427]   
See also in sourсe #XX -- [ Pg.759 ]




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