Hydra - Isoniazid

Salinazid. [(2-Hydroxyphenyl)methy ene]hydra-zide 4-pyridinecarboxyllc acid 1 -isonicotinoyl-2-salicylid-enehydrazine isonicotinic acid salicyltdenehydrazide sali-niazid JV -o-hydroxybenzylidenepyridine -4 car boxy hydra -zide o-hydroxybenzal isonicotinylhydrazone Salizid Nupa-sal At-ozid Nupasal-2 3. CuH.,N302 mol wt 241.24. C 64.72%, H 4.60%, N 17.42%, O 13.26%. Prepd by the interaction of isoniazid and salicylaldebyde in water Hart ei at, Antibiot. Chemother. 4, 803 (1954) cf. Yale r at, J, Am. Chem. Soc. 75, 1933 (1953). Tuberculostatic activity and toxicity Bavin et at, J. Pharm. Pharmacol. 7, 1032 (1955). 

Alpha-picoline (2-picoline 2-methylpryridine) is used for the production of 2-vinylpyridine, which, when copolymerized with butadiene and styrene, produces a product that can be used as a latex adhesive which is used in the manufacture of car tires. Other uses are in the preparation of 2-beta-methoxyethyl-pyridine (known as promintic, an anthelmintic for cattle) and in the synthesis of a 2-picoline quaternary compound (amprolium), which is used against coccidiosis in young poultry. Beta-picoline (3-picoline 3-methylpryridine) can be oxidized to nicotinic acid, which, with the amide form (nicotinamide), belongs to the vitamin B complex both products are widely used to fortify human and animal diets. Gama-picoline (4-picoline 4-methylpyridine) is an intermediate in the manufecture of isonicotinic acid hydra-zide (isoniazide), which is a tuberculostatic drug. 2,6-Lutidine (2,6-dimethylpyridine) can be converted to dipicolinic add, which is used as a stabilizer for hydrogen peroxide and peracetic acid. 

Fig. 1 (a) Rifampin (Rifamycin, 3-[[(4-methyl-l-piperazinyl)-imino]methyl]-, 5,6,9,17,19,21-Hexahydroxy-23-methoxy-2, 4,12,16,18,20,22-heptamethyl-8-[A -(4-methyl- l-piperazinyl)for-mimidoyl]-2,7-(epoxypentadeca[ 1,11,13]trienimino)naphtho[2,1 -l)]furan-l,ll-(2/f)-dione 21-acetate, [13292-46-1]). C43H58N4O12, MW = 822.94. (b) Isoniazid (4-Pyridinecarboxylic acid, hydra-zide, isonicotinic acid hydrazide, [54-85-3]). CgHyNsO, MW = 137.14. (c) Pyrazinamide (Pyrazinecarboxamide,... 

For the sake of completeness, we conclude by mentioning a carbonic acid hydra-zide, namely pyridine-4-carboxylic acid hydrazide (isonicotinic acid hydrazide, Isoniazide), an amide compound with a major potential for antimicrobial efficacy but also general toxicity, which is an obstacle to its practical application as a microbicide for the protection of materials. 

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