5- hydantoin sodium salt

Common Name 1-[ [5-(p-nitrophenyl)furfurylidene]-amino] hydantoin sodium salt... 

T-Ethylpentyl)hydantoin sodium salt Chlordantoin 1 -Ethylpiperidine... 

Perchloromethylmercaptan is reacted with the sodium salt of 5-(1-ethylpentyl)hydantoin. 

Imines, sulfonamides, and hydantoins undergo copper-catalyzed arylation by aryllead triacetates in the same manner. In many cases, prior conversion of the N-H bonds into the corresponding sodium salts is recommended.43 44... 

Alkylation of the hydantoin (89-2) from benzaldehyde with ethyl iodide takes place at the imide nitrogen to afford ethitoin (89-3) [93]. In much the same vein, treatment of the hydantoin (89-5) from propiophenone with methyl iodide (89-5) in the presence of a base affords mephenytoin (89-6) [94]. Replacement of the quite acidic imide proton by an aUcyl group is not required for activity the well-known anticonvulsant phenytoin (89-8) consists of simply the hydantoin obtained from benzophenone (89-7) [95] this is often formulated as its sodium salt. 

Quaternary ammonium salts of dantrolene and clodanolene have been prepared, and the effect of the organic cation on the aqueous solubility has been reported (Ellis et al., 1980). It was reasoned that since the hydantoin moiety in each drug is weakly acidic, a strong base should be found for salt formation. The 13 different quaternary ammonium compounds were therefore used in the hydroxide salt form. The acid-base reaction proceeded rapidly, and the salt products were stable during recrystallization steps. Of the four salts for clodanolene, the aqueous solubilities ranged from 2- to 100-fold that of clodanolene sodium, on a mass basis. Of the 11 salts for dantrolene, the benzyl-trimethyl ammonium salt exhibited comparable solubility to that of dantrolene sodium. Among the other 10 salts were several examples that yielded enhanced solubilities of up to 1000-fold that of the sodium salt. Twelve of the Lfteen salts successfully demonstrated muscle relaxant activity when administered orally. 

HI HYDANTOIN, l-<(5-( p-HITROPHEHYUFURFURYLIOEHE>AMINO, SODIUM SALT, HEMIHEPTAHTDRATE... 

Early syntheses of SeMet were tedious, non-stereospecific or limited to small-scale preparations. Klosterman and Painter (1947), for example, first reacted 5-((3-bromoethyI)- hydantoin with benzyl selenol to yield y-benzylselenoho-mocysteine. The latter was converted to the sodium salt of DL-selenohomo-cysteine with sodium in liquid ammonia, and reacted with methyl iodide to yield DL-SeMet. Plieninger (1950) obtained DL-SeMet by the reaction of sodium selenomethyl mercaptide with a-amino-y-butyrolactone in an inert solvent at 170°C. A synthesis of DL-SeMet from acrolein was also described (Zdansky, 1968). The first stereospecific synthesis of L-SeMet via esters of tosylated homoserine was reported by Pande et al. (1970). 

In the second major class of amine derivatives, the amidic nitrogen atom can also be A-arylatcd when the sodium salt of the amides is treated with /wra-tolyllead triacetate 58 in CH2C12-DMF at 60-80 °C under mild conditions113,114 (Equations (91)-(93)). Amides as well as sulfonamides, imides, or hydantoins reacted with aryllead triacetates under copper(ll) catalysis, to afford good to excellent yields of the derived A-arylamidcs. In general, better yields were obtained when the sodium salt of the amide was used. For these amidic substrates, the reactions are... 

DIPHENTOIN DIPHENYLAN SODIUM DIPHENYLHYDANTOIN SODIUM 5,5-DIPHENYL-HYDANTOIN SODIUM 5,5-DIPHENYL-2,4-IMIDAZOLIDINE-DIONE, MONOSODIUM SALT DI-PHETINE DITOIN DIVULSAN DPH ENKEFAL... 

Phenytoin Sodium, USP. Phenytoin sodium. 3.3-di-phenyl-2.4-imidazolidinedionc. 3.3-diphenylhydantoin. di-phenyl-hydantoin sodium (Dilantin), has bran used for decades in the control of grand mal types of epileptic. seizure. It is structurally analogous to the barbiturates but docs not possess their extensive sedative properties. The compound is available as the sodium salt. Solutions for parenteral administration contain 40% propylene glycol and 10% alcohol to dis.solvc the sodium salt. 

Rubino (1989) has investigated the solid-state properties of the sodium salts of drugs (e.g., barbiturates, sulphonamides and hydantoins). When the logarithm of their aqueous... 

Phenytoin is the prototype and most commonly prescribed member of the hydantoin family of drugs. Bioequivalency is a problem with the hydantoins because of their very poor water solubility ( 32 mg/L) and a low therapeutic ratio. Phenytoin exhibits nonlinear pharmacokinetics that exaggerate the effects of changes in the fraction of dose absorbed. Its apparent pKa is in the range of 8.06 to 8.33 and, thus, can form a water-soluble sodium salt ( 15 mg/mL at solution pH >11). ... 

Bromic acid, sodium salt. See Sodium bromate Bromic ether. See Ethyl bromide BromiCide . See 1-Bromo-3-chloro-5,5-dimethyl hydantoin Bromide Pius. See,Sodium bromide Bromide salt of potassium. See Potassium bromide... 

Dichioro-5,5-dimethyl hydantoin Didecyidimonium chioride Diisobutyl sodium sulfosuccinate Dimethyiamine Dimethyiaminopropyiamine Dioctyi sodium suifosuccinate Hydrogenated taiiowamine Hydrogenated tallowtrimonium chioride iodine Lithium hypochlorite Maieic acid/acrylic acid copolymer Maleic acid/olefin copolymer, sodium salt Manganese acetate (ous) Mineral oil Montmorillonite... 

The conversion of 34 into BIRT 377 is rather efficient and very atom-economical. Treatment with 1.1 eq. MeOLi in methanol at rt provides the methyl ester of the protected amino acid along with 4-phenyl benzaldehyde. Addition of aqueous sodium bisulfite precipitates the aldehyde as the bisulfite adduct which can be removed by filtration. The crude methyl ester is then refluxed in toluene with the sodium salt of 3,5-dichloroaniline to afford hydantoin 35, which is then iV-methylated using LiHMDS/Mel in DMF to provide the final product. This sequence provides BIRT 377 in excellent purity in 40% overall yield over 5 steps, starting in this case from readily available (L)-A -/-butoxycarbonylalanine. 

Amino-3-carboxy-l-propyl Methyl Tellurium1 In a Teflon-lined bomb are placed 40 mg (0.15 mmol) of 5-(/)-methyltelluroethyl)-hydantoin and 1 ml of 1 M aqueous sodium hydroxide solution. The mixture is heated at 165° for 1 h and then cooled. The solution is carefully acidified with 10% aqueous sulfuric acid, filtered, and the filtrate is lyophilized. The product, a tan-colorcd solid, is a mixture of the desired compound with inorganic salts which is not further purified. 

Introduction of a C-glycyl [—CH(NH2)C02H] side-chain has been accomplished in the case of the 3-ulose in Scheme 2, by either reaction with methyl 2-nitroacetate, followed by reduction and hydrolysis, or by reaction of the corresponding C-formyl derivative with sodium cyanide, ammonium carbonate, and carbon dioxide, followed by hydrolysis (Bucherer hydantoin procedure) (Scheme 4). A C-formyl side-chain can be established from a nitromethyl side-chain by oxidation of the sodium acinitronate salt by Ti chloride at pH 1. Several C-formyl branched-chain sugars have been synthesized in this way. ... 

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