Hyaluronic acid chemical crosslinking

Thus, ionizing radiation provides an excellent tool to reduce the molecular weight of a carbohydrate polymer whenever required for medicinal application, e.g. in the case of chitosan [83-85]. On the other hand, an increased stability against free-radical induced depolymerization might be required. This may be achieved by chemically crosslinking the native linear polymer the radiolytic behaviour of cross-linked hyaluronic acid, called hylan, has been studied [86]. 

A combination of hyaluronic acid and carboxymethyl cellulose was chemically crosslinked to form a barrier membrane that is used clinically as Sepra-film for preventing POA. Another form of crosslinked hyalmonic acid is used clinically for reducing POA under the trade name Inceif . ... 

Kurkowski RA. Chemical crosslinking, compatibilization, and direct molding of an ultra high molecular weight polyethylene and hyaluronic acid microcomposite. Fort Collins Colorado State University 2007. 

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