Hyaluronan derivatives

We prepared a phenol-containing hyaluronan derivative, which was inter-molecularly coupled by HRP to yield a crosslinked hydrogel (Scheme 27). The sequenhal injection of this hyaluronan derivative and peroxidase formed... 

Pritchard K., et al., Evaluation of the bioadhesive properties of hyaluronan derivatives detachment weight and mucociliary transport rate studies, J. Pharm., 129, 137, 1996. 

Pritchard, K., Lansely, A. B., Martin, G. P., Helliwell, M., Marriott, C., and Benedetti, L. M. (1996), Evaluation of bioadhesive properties of hyaluronan derivatives, detachment weight and mucociliary transport rate studies, Int. J. Pharm., 129,137-145. 

For several years I tried to convince Pharmacia to work with me to develop new derivatives of hyaluronan and test them on a broad spectrum of medical therapeutic applications. But Pharmacia was not even ready to market my high molecular weight, non-inflammatory fraction of hyaluronan for the treatment of human arthritis, despite the fact that they had many successful clinical trials and that they were selling the material worldwide for treatment of arthritis in animals. I believe that this was because they were not ready to invest in a substantially larger manufacturing facility for hyaluronan. They were, however, ready to support me financially in my research and development effort to develop new hyaluronan derivatives. 

Ghezzo E, Beredetti LM, Rochira M, et al. Hyaluronan derivative microspheres as NGF delivery devices preparation methods and in vitro release characterization. Int ] Pharm 1992 29 133-141. 

Benedetti L, Cortivo R, Berti T, Berti A, Pea F, Mazzo M, Moras M, Abatangelo G. Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats. Biomaterials 1993 14 1154-1160. 

Pozo MA, Balazs EA, Belmonte C. Reduction of sensory responses to passive movements of inflamed knee joints by hylan, a hyaluronan derivative. Exp Brain Res 1997 116 3-9. 

Orlandi RR, Shu XZ, McGill L, Petersen E, Prestwich GD. Structural variations in a single hyaluronan derivative significantly alter wound-healing effects in the rabbit maxillary sinus. Laryngoscope 2007 117 1288-1295. 

Renier D, Bellato P, Bellini D, Pavesio A, Pressato D, Borrione A. Pharmacokinetic behaviour of AGP gel, an autocrosslinked hyaluronan derivative, after intraperitoneal administration. Biomaterials 2005 26 5368-5374. 

Liu Y, Shu X Z and Prestwich G D (2007c), Tumor engineering orthotopic cancer models in mice using ceU-loaded, injectable, cross-linked hyaluronan-derived... 

Serban M A, Scott A and Prestwich G D (2008b), Use of hyaluronan-derived hydrogels for three-dimensional cell cultme and tumor xenografts , Curr Protoc Cell Biol, Chapter 10, Unit 10 14. 

Yang G, Espandar L, Mamahs N and Prestwich G D (2010), Accelerated repair of comeal epithehal abrasion and aUsah bum injuries in rabbits with a crosslinked hyaluronan derivative . Vet. Ophthalmology, 13, 144-50. 

Trochon, V., Mabilat-Pragnon, C., Bertrand, P., Legrand, Y, Soria, J., Soria, C., Delpech, B., and Lu, H. (1997). Hyaluronectin blocks the stimulatory effect of hyaluronan-derived fragments on endothelial cells during angiogenesis in vitro. FEBS Letters 418,6-10. 

Cowman, M.K., Li, M., Dyal, A., Balazs, E.A. (2000) Tapping mode atomic force microscopy of the hyaluronan derivative, Hylan A. Carbohydrate Polymers, 41 (3), 229-235. 

Tetrahedron Asym., 2005,16, 39-44 (c) C. Di Meo, L. Panza, D. Capitani, L. Mannina, A. Banzato, M. Rondina, D. Renier, A. Rosato, V. Crescenzi. Hyaluronan as carrier of carboranes for tumor targeting in boron neutron capture therapy. Biomacromolecules, 2007, 8, 552-559 (d) C. Di Meo, L. Panza, R Campo, D. Capitani, L. Mannina, A. Banzato, M. Rondina, A. Rosato, V. Crescenzi. Novel types of car-borane-carrier hyaluronan derivatives via click chemistry . Macromol. Biosci., 2008, 8, 670-681. 

Several polysaccharides, such as hyaluronan and alginate, have also been examined as potentially suitable biomaterials for hPSC expansion [80-83]. Polysaccharide is known to play an important role in regulating hPSC adhesion and self-renewal [74]. For example, hyaluronan-derived hydrogels might provide an adequate physiological environment for hPSC growth because the feeder layers that support hPSCs are composed of large amounts of hyaluronic acid in addition to abundant ECM proteins. 

Band PA. Hyaluronan derivatives chemistry and clinical applications. In Laurent TC, editor. The chemistry, biology and medical applications of hyaluronan and its derivatives. London Portland Press Ltd 1998. p. 33M2. 

Grigolo B, Roseti L, Fiorini M, Fini M, Giavaresi G, Aldini NN, et al. Transplantation of chrondrocytes seeded on a hyaluronan derivative (HYAFF-ll)intocartilagedefectsinrabbits.B/omaferM/s2001 22(17) 2417-24. 

Scheme 12 Hyaluronan-derived CuAAC cross-linked hydrogels 42...

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