Human immunodeficiency virus protease nonpeptidic

Reich SH, Melnick M, Davies JF, Appelt K, Lewis KK, Fuhry MA, Pino M, Trippe AJ, Nguyen D, Dawson H, Wu B-W, Musick L, Kosa M, Kahil D, Webber S, Gehlhaar DK, Andrada D, Shetty B. Protein structure-based design of potent, orally bioavailable, nonpeptide inhibitors of human immunodeficiency virus protease. Proc. Natl. Acad. Sci. 1995 92 3298-3302. 

Poppe SM, Slade DE, Chong K-T, et al. Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor. Antimicrob Agents Chemother 1997 41 1058-1063. 

S. H. Reich, M. Melnick, J. F. Davies 11, K. Appelt, K. K. Lewis, M. A. Fuhry, M. Pino, A. J. Trippe, D. Nguyen, H. Dawson, B.-W. Wu, L. Musick, M. Kosa, D. Kahil, S. Webber, D. K. Gehlhaar, D. Andrada, and B. Shetty, Proc. Natl. Acad. Sci. USA, 92,3298 (1995). Protein Structure-Based Design of Potent Orally Bioavailable, Nonpeptide Inhibitors of Human Immunodeficiency Virus Protease. 

Erickson-Viitanen, S., Klabe, R. M., Cawood, P. G. et al. 1994. Potency and selectivity of inhibition of human immunodeficiency virus protease by a small nonpeptide cychc urea, DMP 323. Antimicrob. Agents Chemother. 38 1628-1634. 

DesJarlais RL, Seibel GL, Kuntz ID, Furth PS, Alvarez JC, Ortiz de Montellano PR, DeCamp DL, Babd LM, Craik CS. Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease. Proc Natl Acad Sci USA 1990 87 6644-8. 

D. L. DeCamp, L. M. Babe, and C. S. Craik, Proc. Natl. Acad. Sci. U.S.A. 87, 6644 (1990). Structure-Based Design of Nonpeptide Inhibitors Specific for the Human Immunodeficiency Virus 1 Protease. 

Structure-Based Design of Nonpeptide Inhibitors Specific for die Human Immunodeficiency Virus 1 Protease. 

Koh, Y, Nakata, H., Maeda, K. et al. 2003. Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro. Antimicrob. Agents Chemother. 47 3123-3129. 

---