Human growth hormone molecular mass

Human growth hormone is a single polypeptide chain of 191 amino acids (qv) having two disulfide bonds, one between Cys-53 and Cys-165, forming a large loop in the molecule, and the other between Cys-182 and Cys-189, forming a small loop near the C-terminus. The stmcture of hGH is shown in Figure 1 molecular mass is 22,125 the empirical formula is C qH 29N 262 300 7 ... 

Treatment of GH-deficient subjects with human GH (hGH) generally causes a prompt rise in immunoreactive SM-C/IGF-I levels, detectable within a few hours and reaching a peak value approximately 24 hours after administration of the hormone (C19). Similar to SM-C/IGF-I in the serum of healthy subjects, SM-C/IGF-I induced by acute hGH treatment is found mainly in the 150,000-molecular-mass fraction in serum (C19). Rosenfeld et al. (R12) have reported that the rise in serum SM-C/IGF-I in GH-deficient children measured over the first 5 days of hGH treatment is highly predictive of the growth fitctor level determined after 6 months of regular hGH administration. However, there is disagreement as to the relationship be-... 

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