Human diseases respiratory disorders

Sulfur mustards (designated H [mustard], HD [distilled mustard], and HT [HD and T mixture]) do not present acute lethal hazards. Their principal effect is severe blistering of the skin and mucous membranes. Epidemiological evidence indicates a causal relationship between exposure to mustard agent at high concentrations and the development of chronic nonreversible respiratory disorders, such as chronic bronchitis and asthma, and ocular diseases, such as delayed recurrent keratitis and prolonged, intractable conjunctivitis (IOM, 1993). Sulfur mustard has been classified as a known human carcinogen based on evidence of in-... 

CHRONIC HEALTH RISKS cardiovascular diseases respiratory paralysis blood disorders reproductive effects EPA Group B2 probable human carcinogen. 

As would be expected, khat overuse produces symptoms similar to those of other monoamine stimulants, such as cocaine or amphetamine, including signs of sympathetic overarousal. In the extreme this can involve a toxic psychosis. Disorders more frequently associated with chronic khat use in males are headaches, anorexia, insomnia, constipation, and respiratory illnesses (Kennedy et al. 1983). Females report higher incidences of acute gastritis, jaundice, bronchitis and hepatic diseases. Also, cathinone has toxic reproductive effects in humans and experimental animals (Islam et al. 1990). It decreases sperm count and motility, and increases the number of abnormal sperm cells. It also decreases plasma testosterone in rats. 

Much is known about the induction of drug toxicity in animals and humans. A variety of drugs have been used for the treatment of human health disorders. Occupational workers, young, adult men, women, and pregnant women often become victims when exposed to chemicals and drugs in workplaces. Many drugs and related chemicals are known to disturb and induce respiratory diseases in such exposed workers. Therefore, it is important to monitor and properly manage workers health to achieve safety. 

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