Human diseases and

Brodsky JL, Chiosis G (2006) Hsp70 molecular chaperones emerging roles in human disease and identification of small molecule modulators. Curr Top Med Chem 6 1215-1225... 

Membrane polyunsaturation also has potential in the treatment of human disease and trials of this approach are somewhat further along than with NO. For example, highly polyunsaturated omega-3 fatty acids are being... 

Characteristics of human diseases and conditions caused by eating seafood contaminated with phycotoxins. 

When disposed of improperly, hazardous solid wastes may contaminate air, soil, and/or groundwater, and increase the risk of human disease and environmental contamination. 

Since the discovery of penicillin, an enormous number of antibiotic compounds have been isolated. They have found uses both in treatment of human disease and in various aspects of agriculture, including treatment of animal and plant diseases, and as feed additives to promote growth of animals. Some antibiotics such as tylosin were developed specifically for agricultural use. 

In recent years, concern that chemicals might inadvertently be disrupting the endocrine system of humans and wildlife has increased. The concerns regarding exposure to these endocrine disrupters are based on adverse effects observed in certain wildlife, fish, and ecosystems increased incidences of certain endocrine-related human diseases and adverse effects observed in laboratory animals exposed to certain chemicals. The main effects reported in both wildlife and humans concern reproductive and sexual development and function altered immune system, nervous system, and thyroid function and hormone-related cancers. Endocrine dismption is not considered a toxicological endpoint in its own right, but a functional change or toxicological mode(s) of action that may lead to adverse effects. Endocrine dismpters are addressed further in Section 4.11. 

In this volume we want to present the state of the art of epigenetics with regard to drug discovery. The chapters are divided into two major sections one series of articles deals with the methodology that is available and the other presents the targets, their link to human diseases and available inhibitors. We apologize to all scientists whose efforts in the field were not duly dted in this book. We thank our authors, the publishers at Wiley-VCH and our families for support. 

Drevets, D. A. and Bronze, M. S. (2008). Listeria monocytogenes Epidemiology, human disease, and mechanisms of brain invasion. FEMS Immunol. Med. Microbiol. 53,151-165. 

Molecular-Clinical Interface Human Disease and Enzyme Cofactors... 

The fundamental mechanistic causes of human disease and pathology are multiple, but they can be comprehensively categorized into the following ten groups ... 

Taams LS, Palmer DB, Akbar AN, Robinson DS, et al. 2006. Regulatory T cells in human disease and their potential for therapeutic manipulation. Immunology. 118 1-9. 

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