Human cerebral cortex, regulation

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In the normal adult human brain, the cells expressing the Di mRNA are localized predominantly within the striatum, cerebral cortex and bed nucleus of the stria terminalis (Hurd et al., 2001). There is extremely low or no appreciable detection of D mRNA expression in the hippocampus, diencephalon, brainstem, or the cerebellum indicating that neurons situated in those regions have no major role in mediating Di receptor regulated functions in marked contrast to the multitude of D2 and D3 receptor mRNA-expressing neurons in discrete populations in some of these brain areas (see Sections 2.3.3 and 2.3.5). 

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