Human brain, gene expression

Solano, S. M., Miller, D. W., Augood, S. J., Young, A. B., Penney, J. B., Jr. 2000. Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase LI mRNA in human brain genes associated with familial Parkinson s disease. Ann Neurol 47 201-10. 

Meador-Woodruff J., Little K., Damask S., Mansour P., Watson S. Effects of cocaine on dopamine receptor gene expression A study in the postmortem human brain. Biol. Psychiatry. 34 348, 1993. 

Roncero, I., Alvarez, E., Chowen, J. A. et al. Expression of glucose transporter isoform GLUT-2 and glucokinase genes in human brain. J. Neurochem. 88 1203-1210, 2004. 

This isoform was found as the result of a mouse deficient in the oxysterol 7a-hydroxylase gene (CYP7B1 in humans), which nonetheless did not accumulate 24-hydroxy cholesterol from the CYP46pathway, suggesting the existence of another 7ot-hydroxylase (Li-Hawkins et al., 2000). However, very httle evidence exists for its expression in human brain. Nishimura et al. quantified CYP39A1 mRNA by RT-RT-PCR and reported some 100-fold less than they reported for CYP51 mRNA (Nishimura et al., 2003). There is no other evidence for the expression of this isoform in the brain as of this writing and this is beheved to be the first report of its kind. The isoform has been shown to be sexually dimorphic in the liver (Li-Hawkins et al., 2000). 

Yu L, Romero DG, Gomez-Sanchez CE, Gomez-Sanchez EP. 2002. Steroidogenic enzyme gene expression in the human brain. Mol Cell Endocrinol 190 9-17. 

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