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Human blood group substances

Figure 9.12 Deoxy derivatives. These contain one less oxygen atom than the monosaccharide from which they are derived. 2-Deoxyribose is a most important deoxy pentose and is a major constituent of deoxyribonucleic acid (DNA). Deoxy hexoses are widely distributed among plants, animals and microorganisms especially as components of complex polysaccharides. Examples are rhamnose (6-deoxymannose), a component of bacterial cell walls, and fucose (6-deoxygalactose), which is often found in glycoproteins and is an important constituent of human blood group substances. Figure 9.12 Deoxy derivatives. These contain one less oxygen atom than the monosaccharide from which they are derived. 2-Deoxyribose is a most important deoxy pentose and is a major constituent of deoxyribonucleic acid (DNA). Deoxy hexoses are widely distributed among plants, animals and microorganisms especially as components of complex polysaccharides. Examples are rhamnose (6-deoxymannose), a component of bacterial cell walls, and fucose (6-deoxygalactose), which is often found in glycoproteins and is an important constituent of human blood group substances.
The continuous heavy line represents the protein core (MW, ca. 300,000). The short lines represent oligosaccharides or small polysaccharides as side chains. These side chains may be as small as one or as large as five sugar residues for the types found in BSM, OSM, and PSM. The longer side chains are more of the type formed in the human blood-group substances, any one may be as long as 20 units. [Pg.229]

Fig. 9. Proposed composite structure showing the relationship of the A, B, H, Le , and Le antigenic determinants of the water-soluble human blood group substances from ovarian cysts. The structure of the side chain in brackets has not been established, but the existence of such a chain is indicated by the mechanism of alkaline borohydride degradation and the oligosaccharides isolated. The carbohydrate chain shown is one of many linked to the serines and threonines of the polypeptide backbone. Chains are not homogeneous and may be of various lengths depending upon genetic composition, incomplete biosynthesis, and unknown factors. From Pereira and Kabat, modified from Lloyd and Kabat cf. Kabat. ... Fig. 9. Proposed composite structure showing the relationship of the A, B, H, Le , and Le antigenic determinants of the water-soluble human blood group substances from ovarian cysts. The structure of the side chain in brackets has not been established, but the existence of such a chain is indicated by the mechanism of alkaline borohydride degradation and the oligosaccharides isolated. The carbohydrate chain shown is one of many linked to the serines and threonines of the polypeptide backbone. Chains are not homogeneous and may be of various lengths depending upon genetic composition, incomplete biosynthesis, and unknown factors. From Pereira and Kabat, modified from Lloyd and Kabat cf. Kabat. ...
Lactosamine and isolactosamine (lactosamine analogue with D-galactopyranose linked to A-acetyl-D-glucosamine) are a well characterized set of (7-linked oligosaccharides that make up the ABO human blood group substances [148]. They are on the surface of erythrocytes and divide human blood into four distinct types. The following core structure makes up the 0-blood type and is found in all four blood types ... [Pg.89]

Mil. Morgan, W. T. J., and Watkins, W. M., Inhibition of haemagglutinins in plant seeds by human blood group substances and simple sugars. Brit. J. Exp. Pathol. 34, 94-103 (1953). [Pg.58]

Among the tetra- and penta-saccharides to be synthesized were (53)/ (54) (the repeating-unit of the O-specific polysaccharide from Salmonella senftenberg), a derivative of (55), (56) (in connection with immunological studies of the blood-group substances), and (57) (one of the core oligosaccharides of human blood-group substances). ... [Pg.29]

Closely related are the serologically type-specific substances from the capsules of certain pneumococci. Some of these substances contain hexos-amines and the structure (LVI) proposed (How el al., 1964) for one of these (Type 14) is of special interest since it cross-reacts serologically with the core of certain human blood group substances (see XXXXIII). [Pg.460]


See other pages where Human blood group substances is mentioned: [Pg.9]    [Pg.43]    [Pg.214]    [Pg.243]    [Pg.343]    [Pg.259]    [Pg.263]    [Pg.339]    [Pg.272]    [Pg.995]    [Pg.339]    [Pg.995]    [Pg.32]    [Pg.34]    [Pg.508]    [Pg.466]    [Pg.14]    [Pg.14]    [Pg.275]   
See also in sourсe #XX -- [ Pg.276 , Pg.277 ]




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