Huisgen, Rolf

The father of miinchnone chemistry, Rolf Huisgen, reported (130) the 1,3-dipolar cycloaddition of miinchnone 38 with p-nitrophenyldiazonium salt 226 to give the triazolium salt 227. This reaction would appear to be an important new route to these heterocycles. 

Submitted by Ingrid Bruning, Rudolf Grashey, Hans Hauck, Rolf Huisgen, and Helmut Seidl 1 Checked by Robert Eliason, Wayland E. Noland, and William E. Parham... 

Makhluf Haddadin Thomas M Harris Hans Hauck Charles R Hauser G K Helmkamp F M Hinga Derek Horton Rolf Huisgen B A Johnson Carl R Johnson F Johnson... 

We thank the National Institute of Health for generous support of our research program in the area of dipolar cycloaddition chemistry. Dedicated with respect and admiration to Professor Rolf Huisgen, the leading authority in the area of dipolar cycloaddition chemistry, on the occasion of his 70th birthday. 

R. Sustmann, Rolf Huisgen s Contribution to Organic Chemistry, Emphasizing 1,3-Dipolar Cycloaddi-tions, Heterocycles 1995, 40, 1-18. 

A very recommended reading is a review [250] by the master of this field, Rolf Huisgen, and co-workers. They highlight specific features of thiocarbonyl compounds ... 

Later in life, two colleagues changed my career decisively. I became John Pople s disciple John s conceptions converted me to applied theoretical chemistry. Rolf Huisgen was both an inspiring chemist and a genial, cultured host. The positive experiences of my two sabbaticals and several stays with him in Munich led to my move to Erlangen. 

G. K. Helmkamp F. M. Hinga Derek Horton Rolf Huisgen B, A. Johnson Carl R. Johnson F. Johnson... 

In spite of some related reactions discovered in the following 71 years, it was Rolf Huisgen who realized in 1960 that all these reactions were based on the addition of a 1,3-dipole to a dipolarophile (Scheme 1-5). 

CONTENTS Introduction to the Series An Editor s Foreword, Albert Padwa. Preface, Dennis P. Curran. Steiic Course and Mechanism of 1,3-Dipolar Cycloadditions, Rolf Huisgen. Nonstabilized Azomethine Ylides, Edwin Vedejs. Molecular Rearrangements Occurring from Products of Intramolecular 1,3 Dipolar Cycloadditions Synthetic and Mechanistic Aspects, Arthur G. Schultz. Dipolar Cycloadditions of Nitrones with Vinyl Ethers and Silane Derivatives, Philip DeShong, Stephen N. Lander, Jr., Joseph M. LeginusandC. Michael Dickson. The Cycloaddition Approach to b-Hydroxy Carbonyls An Emerging Alternative to the Aldol Strategy, Dennis P. Curran. Index. 

Professor Rolf Huisgen discovered the titled reaction in 1958 at the University of Munich. " Huigen s great intuition drove him to ask his Ph.D. student Jurgen Sauer to repeat failed reactions of 5-phenyltetrazole with aroyl chlorides in pyridine that has been run by an an inept postdoctoral fellow, and hence led to the discovery of the named reaction. Since its discovery, the Huisgen tetrazole rearrangement reaction has been used for the synthesis of... 

The concept of (3 -I- 2)-dipolar cycloadditions, pioneered by Rolf Huisgen, dates back to the early 1960s [19]. Over the years, this reaction has found widespread utility in heterocyclic chemistry, natural product synthesis and medicinal chemistry [20-22]. These elegant chemical transformations facilitate the construction of products with high complexity where two new tj-bonds are formed in a single step. In a typical (3 -I- 2)-dipolar cycloaddition reaction, a 1,3-dipole reacts with a... 

The 1,3-dipolar cycloaddition (1,3-DC) is the reaction of a dipolarophile with a 1,3-dipolar compound to form a five-membered ring, which is a kind of MBFT. The earliest 1,3-DC reactions were described in the late nineteenth century to the early twentieth century, following the discovery of 1,3-dipoles. Mechanistic investigations and synthetic applications were established by Rolf Huisgen in the 1960s [2], Now, the chemistry of the 1,3-DC reaction has thus evolved for more than 100 years, and a variety of different 1,3-dipoles have been discovered, which has significantly advanced the development of the 1,3-DC reactions. After several decades of development, transition-metal-catalyzed, stereoselective 1,3-DC has become one of the most useful synthetic routes to the synthesis of the five-membered heterocycles. 

Dipolar cycloaddition reactions (DCRs) are unique reactions when considering their versatility, their atom economy and the highly functionalized heterocyclic products they provide. The significant contributions by Rolf Huisgen has led to the description of a... 

Deceived by a fabricated report, Wittig failed to demonstrate the symmetrization of the 1- and 2-positions. The teams of Jack Roberts and Rolf Huisgen settled this matter. [l- C]Chlorobenzene was found to give [l- C]- and [2- C]-... 

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