5-HTTLPR polymorphisms

Arias, B., Catalan, R. et al. (2003). 5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study. /. Clin. Psychopharmacol, 23(6), 563-7. 

Auerbach, J., Geller, V., Lezer, S., Shinwell, E., Belmaker, R.H., Levine, J., and Ebstein, R. (1999) Dopamine D4 receptor (D4DR) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants. Mol Psychiatry 4 369-373. 

Praschak-Rieder N, Willeit M, Winkler D, et al. Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with or without premenstrual dysphoric disorder. Eur Neuropsy-chopharmacol 2002 12 129-134. 

Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS, Egan MF, Mattay VS, Hariri AR, Weinberger DR (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions a genetic susceptibility mechanism for depression. Nat Neurosci 8 828-834. 

Mann, J. J., Huang, Y., Underwood, M. D. et al. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch. Gen. Psych. 57 729-738, 2000. 

Rocchi, A., Micheli, D., Ceravolo, R., et al. (2003) Serotoninergic polymorphisms (5-HTTLPR and 5-HT2A) association studies with psychosis in Alzheimer disease. Genet. Test. 7, 309-314. 

Yu YW, Tsai SJ, Chen TJ, Lin CH, Hong CJ (2002) Association study of the serotonin transporter promoter polymorphism and symptomatology and antidepressant response in major depressive disorders. Mol Psychiatry 7 1115-1119 Zanardi R, Benedetti F, Di Bella D, Catalano M, Smeraldi E (2000) Efficacy of paroxetine in depression is influenced by a functional polymorphism within the promoter of the serotonin transporter gene. J Clin Psychopharmacol 20 105-107 Zanardi R, Serretti A, Rossini D, et al (2001) Factors affecting fluvoxamine antidepressant activity influence of pindolol and 5-HTTLPR in delusional and nondelusional depression. Biol Psychiatry 50 323-330... 

Initial pharmacogenetic studies of serotonin transporter gene (HTT) variants used case-control methods and have generated disparate results in different populations. Positive association of the promoter VNTR polymorphism (5-HTTLPR) with clinical response to fluvoxamine was seen in Italian patients with bipolar or unipolar delusional depression subjects with one or... 

Sen S, Burmeister M, Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004 127 85-89. 

Schinka JA, Busch RM, Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol. Psychiatry 2004 9 197-202. 

Seretti A, Kato M, De Ronchi D, et al. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry 2007 12 247-57. 

Susceptibility factors Genetic Impaired platelet function due to SSRIs has been well-documented, and is associated with clinical evidence of an increased bleeding tendency. The mechanism is related to the effect of SSRIs on the serotonin transporter (5-HTTLPR) in the platelet membrane, which leads to reduced platelet serotonin concentrations however, there have been no studies of the relation of genetic polymorphisms of 5-HTTLPR to this pharmacological action. In a prospective pre-post trial of paroxetine, the effect of paroxetine was most pronounced in patients with no La alleles or only a single allele, and was most marked in those with the S/S genotype [36. ... 

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