HP 7686 Solution-Phase Synthesizer Hewlett Packard

Scientists from Neurocrine Biosciences were first who reported on synthesis of 350 individual analogs of triazine 8 (Fig. 36) [93] using the HP 7686 Solution-Phase Synthesizer (Fig. 37). 

Almost 70% of the synthesized analogs of triazine 8 were isolated in 70-95 + % purity and in milligram quantities. Preparation of amines 9 in an additional reaction sequence on the HP 7686 synthesizer demonstrates its application for automating chemical reactions requiring inert atmosphere and absolute solvents. 

The synthesizer easily fits into a chemical hood. Its carousel hosts up to 100 vials that can hold reagents, reaction intermediates, and/or HP solid-phase extraction cartridges (100 or 300 mg size) for purification of synthesized compounds. It has a heating station capable of maintaining temperatures in the range of 30 to 120 °C (in 1 °C increments) for a time specified by the operator. The content of the vials can be easily transferred in wide volume increments (0.001 to 1.6 mL) to any location on the synthesizer, and with high precision. 

Edited by Fulvio Gualtieri Copyright WILEY-VCH Verlag GmbH,2000 

The creation of large numbers of new samples is facilitated by the use of synthesis on solid supports, in large part because the isolation of intermediate products is so easy. In this chapter, I would like to recount three distinct projects with which I have been involved that relate to solid-phase synthesis. 

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