Neurocrine Biosciences

Cypress Biosciences Neurocrine Biosciences Acadia Pharmaceuticals... 

Indiplon (4) is a nonbenzodiazepine sedative, which was in preregistration for the treatment of insomnia in 2006. Indiplon is a potent GABAa receptor agonist with selectivity for the ai subunit. The compound originated at American Cyanamid and was subsequently developed by Neurocrine Biosciences. 

Potera, C. (1993). Team from Neurocrine Biosciences/Stanford identifies specific T cells linked to MS. Genetic Engineering News 13, March 15, 1 23. 

Neurocrine Biosciences NeXstar Pharmaceuticals, Inc. Norse Associates Ontogen Corp. 

The first published report on the utilization of the HP 7686 Solid Phase Synthesizer (Figure 1) for lead optimization of corticotropin-releasing factor, receptor antagonists appeared in 1996 [13]. Scientists from Neurocrine Biosciences were able to use the synthesizer to prepare 350 individual analogs of triazine (1) in about 4 weeks using the reaction shown in Scheme 1 [13] ... 

Scientists from Neurocrine Biosciences were first who reported on synthesis of 350 individual analogs of triazine 8 (Fig. 36) [93] using the HP 7686 Solution-Phase Synthesizer (Fig. 37). 

Slee and co-workers at Neurocrine Biosciences have synthesized 2-amino-A -pyrimidin-4-ylacetamides as adenosine A2a receptor antagonists. A2a is a type of G-protein-coupled receptor (GPCR) known to modulate... 

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