Hotspot prediction

This result was checked by simulation of both CSTR measurements and calculations of tubular reactor incipient runaways. It should be noted that the predicted AT at inflection from CSTR experiments agrees well with measures in tubular simulation. At hotspot the AT to the AT at inflection is between 1.4 and 1.8. Using a multiplier of 1.4 as recommended by Nelson (1974) is safe. 

Related methods for the prediction of hotspots on protein-protein interfaces using virtual mutagenesis and virtual alanine scanning have recently been reviewed by DeLano [34],... 

M. Engels, K. Ethirajulu, B. De Boeck, Validation and application of MetaSite, a computational platform for the prediction and study of metabolic hotspots. Drug Met. Disp., submitted. 

A crystal structure of human P450 51 is not yet available but high resolution structure of the soluble Mycobacterium tuberculosis P450 51 is (ref [1495]). Two notable features are a bent I helix and an open conformation of the BC loop. The bacterial structure has been utilized in consideration of mammalian models, and the SRS predictions do not seem to apply well . Further, the mutation hotspots for known azole-resistant... 

The remainder of this chapter focusses on attributional LCA, which has been most commonly applied for sheep and wool systems, often to provide benchmarking results for a given system or product and to identify hotspots of environmental impacts in wool supply chains. ALCA avoids the need for some of the sensitive assumptions of CLCA (Finnveden et al., 2009) and is supported by recent development of specific guidelines to improve the consistency of application to wool apparel and textiles (LEAP, 2014a BSI, 2014). However, the inherent limitations associated with ALCA that constrain the applicability of results for predicting the influence of a change in supply and demand should be noted. 

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