Host-guest molecular recognition

Figure 15.6 Schematic diagram of the azobenzene nanotube assembly on the complementary a-CD/Au substrates via host-guest molecular recognition and light-induced nanotube detachment and attachment on the a-CD surfaces.20 (Reprinted with permission from I. A. Baneijee et al., J. Am. Chem. Soc. 2003,125, 9542-9543. Copyright 2003 American Chemical Society.)...

A host-guest molecular recognition process of L-tryptophan, with the above various triangular, bowl-shaped Cp Rh-nucleobase/nucleoside/nucleotide cyclic trimer molecular receptors, was also detected in a gas phase by electrospray ionization mass spectrometry.In this case, the supramolecular complex formation was found to occur predominately via non-covalent tt-tt interactions non-covalent hydrophobic forces apparently being weak or nonexistent. Trp-Met-Asp-Phe tetrapeptide with the trimeric-rhodium host [Cp Rh(2 -deoxyadenosine)]3[OTf]3 also formed a host-guest complex in water that is detected in the gas phase. 

Dong SY, Zheng B, Wang F, Huang FH (2014) Supramolecular polymers constructed from macrocycle-based host-guest molecular recognition motifs. Acc Chem Res 47 1982-1994... 

Hu JM, Liu SY (2014) Engineering responsive polymer building blocks with host-guest molecular recognition for functiraial applications. Acc Chem Res 47 2084-2095... 

The host-guest molecular recognition process was also further substantiated by an intermolecular NOE study between 1 and L-Trp. In that study, the line broadening parameter was set to 4 Hz to minimize the subtraction error. When H8 of 1 was irradiated, weak negative intermolecular NOE signals of L-Trp s Ha,... 

Fish et al. also studied two other parameters, along with the above-mentioned electronic effect that appeared to affect the host-guest, molecular recognition process namely, steric and conformational aspects. The importance of the steric effect can be seen with guests, o-, m-, and p-aminobenzoic add, upon interaction with host 1. As the positional isomers of aminobenzoic acids are changed from the ortho, to the meta, and then para positons, the extent of the host-guest interaction is dramatically decreased. The conformational effect is seen with a... 

R.H. Eish et al. - A New, Aqueous H NMR Shift Reagent Based on Host-Guest Molecular Recognition Principles Using a Supramolecular Host [Cp Rh(2 -deoxyadenosine)]3(OT03, J. Org. Chem. 63, 7151, 1998. 

Channel Mimetic Sensing Membranes Based on Host—Guest Molecular Recognition by Synthetic Receptors... 

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