Host-guest chemistry approach

As discussed in this chapter, the fundamental host-guest chemistry of 1 has been elaborated to include both stoichiometric and catalytic reactions. The constrained interior and chirality of 1 allows for both size- and stereo-selectivity [31-35]. Additionally, 1 itself has been used as a catalyst for the sigmatropic rearrangement of enammonium cations [36,37] and the hydrolysis of acid-labile orthoformates and acetals [38,39]. Our approach to using 1 to mediate chemical reactivity has been twofold First, the chiral environment of 1 is explored as a source of asymmetry for encapsulated achiral catalysts. Second, the assembly itself is used to catalyze reactions that either require preorganization of the substrate or contain high energy intermediates or transition states that can be stabilized in 1. 

For conceptually similar approaches, see (a) Ito, Y. Borecka, B. Trotter, J. Scheffer, J. R. Control of Solid-State Photodimerization of fraws-Cinnamic Acid by Double Salt Formation with Diamines. Tetrahedron Lett. 1995, 36, 6083-6086 (b) Amirsakis, D. G. Garcia-Garibay, M. A. Rowan, S. J. Stoddart, J. F. White, A. J. P. Williams, D. J. Host-Guest Chemistry Aids and Abets a Stereospecific Photodimerization in the... 

S. Penades, Host-Guest Chemistry. Mimetic Approaches to Study Carbohydrate Recognition, 2002, pp. 1-241. 

Penades, Soledad, and Jiirgen-Hinrich Fuhrhop. Host-Guest Chemistry Mimetic Approaches To Study Carbohydrate Recognition. Topics in Current Chemistry, no. 218. New York Springer, 2002. 

S. Penades, Host-guest chemistry, mimetic approach to study carbohydrate recognition, Topics Curr. Chem., 218 (2002) 1-241. 

We distinguish between design and combinatorial approaches. In the former the area of host-guest chemistry has inspired the design of functional monomers... 

Turning to host-guest chemistry, an interesting approach to imprinting in aqueous media was reported by Komiyama and colleagues." Here, functionalized j6-cyclodextrins... 

Other morphologies can be obtained, i.e. dendritic nanoclusters and nanotubes, with different chemical approaches which generate a wide variety of different nanoscale architectures and have a promising potential in host-guest chemistry and nanotechnology [76,77]. Asymmetrically functionalized dendritic blocks, e.g. den-drons with polar and apolar groups, self-assemble to produce macromolecules with surfactant properties [78-81]. 

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