Hormonal Ketamine

Lozenges and troehes are solid preparations designed to dissolve or disintegrate slowly in the mouth their base is usually flavored and sweetened. Examples of eom-pounded troehes include anesthetic (lidocaine), hormonal (testosterone), analgesie (ketamine), and antifungal (nystatin) preparations (Table 2). 

THYROID HORMONES ANAESTHETICS -GENERAL-KETAMINE Cases of tachycardia and hypertension when ketamine was given to patients on thyroxine this required treatment with propanolol Uncertain Monitor PR and BP closely... 

Chronic renal disease may also affect metabolism, not necessarily because of impaired metabolism in the kidney, but because of an indirect effect of renal failure on liver metabolism. For example, in animals with renal failure it was observed that there was a decrease in hepatic cytochromes P-450 content, and consequently zoxazolamine paralysis time and ketamine narcosis time were prolonged. Cardiac failure may also affect metabolism by altering hepatic blood flow. However even after heart attack without hypotension or cardiac failure, metabolism may be affected. For example, the plasma clearance of lidocaine is reduced in this situation. Other diseases such as those which affect hormone levels hyper- or hypo-thyroidism, lack of or excess growth hormone, and diabetes can alter the metabolism of foreign compounds. 

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