Homology relation

Table 5.1. Homology relations for main-sequence stars...

The final member of the yeast medium-chain alcohol dehydrogenase superfamily, encoded by the ZTA1 gene, differs in several key aspects from the six putative yeast reductases shown in Fig. 3A. Most important, this enzyme lacks the residues that ligate the catalytic Zn(II) ion, in common with other crystallin homologs. Related metal-free proteins are capable of reducing quinones [53] however, the catalytic activity and substrate specificity of the protein encoded by ZTA1 is currently unknown. 

In addition to the similarities discussed above, bovine and chicken GDH s and Neurospora GDH (NADP) exhibit short stretches of homology relating Neurospora residues 179-197 and 330-348 to bovine residues 198-216 and 342-360, respectively. The precise roles of the homologous residues in these regions is still not apparent. 

Search database Using infoimation available at hand, such as keyword (e.g. name, function if known), biological source, molecular weight, composition, etc to search databases for the identity (sequence is already known) and homology (related sequences exist). 

In the dilute solution region, there occurs globulization of coils (section 3.4). The homologous relation between the size R and N for globules is defined by the general relationship... 

Spreading velocities v are on the order of 15-30 cm/sec on water [39], and v for a homologous series tends to vary linearly with the equilibrium film pressure, it", although in the case of alcohols a minimum seemed to be required for v to be appreciable. Also, as illustrated in Fig. IV-3, substrate water is entrained to some depth (0.5 mm in the case of oleic acid), a compensating counterflow being present at greater depths [40]. Related to this is the observation that v tends to vary inversely with substrate viscosity [41-43]. An analysis of the stress-strain situation led to the equation... 

Homologous series (Section 2 9) Group of structurally related substances in which successive members differ by a CH2 group... 

Prolactin-Like Proteins. A number of prolactin-like proteins (PLPs), which ate distinct from the PLs, have been identified in mminants and rodents (11,23). Several cDNA transcripts coding for PLPs in catde have been identified (23). These transcripts code for proteins which possess about 40% sequence homology with bovine PRL 60% if conservative substitutions ate considered. Three glycosylated PLPs, ie, PLP-A, -B, and -C, ate produced during pregnancy in the rat (11). Two additional prolactin-related molecules have been identified in the mouse (24,25), ie, proliferin [92769-12-5] (PLF) and PLF-related protein [98724-27-7]. These ate not found in other rodents and may be unique to the mouse. The functional roles of PLPs remain to be deterrnined. 

Insulin and Amylin. Insulin is a member of a family of related peptides, the insulin-like growth factors (IGFs), including IGF-I and IGF-II (60) and amylin (75), a 37-amino acid peptide that mimics the secretory pattern of insulin. Amylin is deficient ia type 1 diabetes meUitus but is elevated ia hyperinsulinemic states such as insulin resistance, mild glucose iatolerance, and hypertension (33). Insulin is synthesized ia pancreatic P cells from proinsulin, giving rise to the two peptide chains, 4. and B, of the insulin molecule. IGF-I and IGF-II have stmctures that are homologous to that of proinsulin (see INSULIN AND OTHER ANTIDIABETIC DRUGS). 

---