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Hodgkin lymphoma cytokines

It has been shown that expression of translation initiation factors eIF-4E and eIF-2alpha is increased in neoplastic cells of Hodgkin lymphoma, but not in surrounding lymphocytes. An increase in eIF-4E expression may lead to constitutively high expression of NF-kB. H/RSCs have high expression of c-FEIP, which protects cells from apoptosis.Tissue inhibitor of metal-loproteinases (TIMP-1 and TIMP-2) are proteins with proteinase inhibition and cytokine properties. TIMP-1... [Pg.143]

Skinnider BE, Mak TW. The role of cytokines in classical Hodgkin lymphoma. Blood. 2002 99 4283-4297. [Pg.154]

Immune dysfunction and poor tumor-specific immune responses are observed in cancer patients with enhanced Treg cell activity. Furthermore, many different types of tumors possess high frequency of Treg cells that inhibit various immune functions including T-cell proliferation, cytokine production and cytotoxic activity. Trl cells also participate in a poor anticancer response. The infiltrating lymphocytes in Hodgkin s lymphoma contain both Treg and Trl cells that suppress various immune functions. [Pg.222]

See other pages where Hodgkin lymphoma cytokines is mentioned: [Pg.143]    [Pg.143]    [Pg.195]    [Pg.377]    [Pg.516]    [Pg.112]    [Pg.374]    [Pg.302]    [Pg.236]    [Pg.655]    [Pg.664]    [Pg.152]    [Pg.91]    [Pg.1175]    [Pg.347]    [Pg.634]    [Pg.340]    [Pg.174]   
See also in sourсe #XX -- [ Pg.143 ]



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