HIV inhibition

Betunilic acid (65) Triterpenoid Bevirimat (PA-457) (66) Antiviral (anti-HIV) Inhibits the final step of the HIV Gag protein processing and tiius blocks HIV maturation Phase 11b Panacos Pharmaceuticals 566-573... 

Atazanavir 87, a 2-arylsubstituted pyridine derivative, is used as an antiviral AIDS drug <1998USP5849911>. Nelfinavir mesilate 88 has found use as an antiviral agent <1994DDR1043>. Potential drugs for HIV inhibition that contain pyridine functionalities are Sch-C 89 and Sch-D 90 <2003MI30>. 

HIV-1 RT HIV-2 RT [antiviral, HIV inhibition, inhibits cellular formation syncytium formation]... 

Conceptually, there are three primary methods of therapeutic intervention against HIV inhibition of viral replication, vaccination to stimulate a more effective immune response, and restoration of the immune system with immunomodulators. Several approaches for an... 

Fig. (41). Salaspermic acid and related compounds assayed for anti-HIV activity Table 7. HIV Inhibition by Salaspermic Acid (156) and Related Compounds...

Fig. 17. Structures of guanidinoglycosides with potent HIV inhibition activity. ...

C6H.3N04, Mr 163.17, mp. 192-195 °C, [a] +47.5° (H2O). D. is a glucose-like piperidine derivative from the bark of the mulberry tree Moms). It can also be obtained by fermentation from Streptomyces species. On account of their ability to inhibit intestinal a-glu-cosidases, D. derivatives have been developed as oral antidiabetic drugs (e.g., Miglitol , Emiglitate ). D. derivatives also exhibit antiviral activity against Hiv (inhibition of the glycosylation of viral proteins). 

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