History of mass spectrometry

A History of Mass Spectrometry http //masspec.scripps.edu/information/history/... 

Many books deal with general mass spectrometry [6-10]. In recent mass spectrometry books, little specific attention has been paid to polymer additives. De Hoffmann and Stroobant [11] and others [12] have traced the history of mass spectrometry. 

Detailed accounts of the history of mass spectrometry and the detection of isotopes are given by Ewald and Hintenberger,70 de Bievre,10 Kienitz,71 Brunnee,72,73 Duckworth et al.,74 de Laeter1 and Budzikiewicz and Grigsby.75... 

Early in the history of mass spectrometry (MS), large biomolecules were not analyzed because efficient methods to transport these molecules into the gas phase were unknown. Degradation typically occurred during vaporization of these nonvolatile molecules so that electron ionization of the intact molecular ion was not possible. Ionization by fast atom bombardment (FAB), field desorption (FD), secondary ionization mass spectrometry (SIMS), and plasma desorption (PD)" from the radioactive decay of Cf finally made the ionization and analysis of peptides possible. These latter techniques, although still used today, are not as popular as electrospray... 

In this introductory chapter, some basic concepts of mass spectrometry were discussed. A brief history of mass spectrometry was presented. Mass spectrometry has its roots in early work with the cathode-ray tube but now it is a more mature discipline and an indispensable analytical tool. It is used primarily to determine the mass of atomic and molecular species and to structurally characterize and quantify a very broad range of componnds. The major assets of this technique are specificity, sensitivity, and ability to analyze real-world samples. 

History of Mass Spectrometry Imaging (MSI) and Microprobing Techniques... 

Thus this spectrometer has become one of the most successful new developments in the history of mass spectrometry (produced by two vendors) and today the instrument is one of the key tools in protein, peptide, and DNA research all over the world [154J. 

The history of mass spectrometry (MS) started in 1912, when Thomson [4] obtained the mass spectra of compounds such as O2, N2, CO, CO2 and COCI2. These findings were based on the earlier discovery of positive ions by Goldstein (1886) and the deflection of ions in a magnetic field by Wien (1898). Subse-... 

Hemmersbach, P. (2008) History of mass spectrometry at the Olympic Games. Journal of Mass Spectrometry, 43, 839-853. 

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