Histological demonstration

Mjor, I. A. (1977). Histological demonstration of bacteria subjacent to dental restorations. Scandinavian Journal of Dental Research, 85, 169-74. 

Salazar I., Barber P.C. and Cifuentes J.M. (1992). Anatomical and immuno-histological demonstration of the primary neural connections of the vomeronasal organ in the dog. Anat Rec 233, 309-313. 

Figure 8.15 Histological demonstration of dermal powder injection in the pig. The stratum corneum (SC), dermis (D), and particles delivered to the epidermis (ED) are clearly shown. The particles consist of swellable, slowly soluble polysaccharide microspheres (50 pm diameter when dry). [With modifications from Hickey (2001). Reproduced with permission from Euromed Communications.]...

Three patients with busulfan-induced interstitial pneumonitis each had circulating immune complexes and alveolitis, and histology demonstrated consistent abnormalities of type I pneumocytes and depletion of type II pneumocytes (7). 

Skeletal disease is common in patients with renal failure treated by chronic dialysis. The majority of these patients have histologically demonstrable bone disease, even in the absence of clinical symptoms (B21). However, serum alkaline phosphatase activities are either within reference limits or only moderately elevated (B21), with spectacular elevations occurring only rarely in both adults (B21, KIO) and children (P34). High serum alkaline phosphatase values have been described in patients on chronic dialysis with severe hypophosphatemic osteomalacia (M3). 

Generally, the diagnosis of toxoplasmosis in man may be done by serologic tests, PCR (which involves the amplification of specific nucleic acid sequences), histologic demonstration of the parasite, or by isolation of the protozoan that might be done by an animal infectivity assay or inoculation in human tissue cell cultures (Montoya, 2002). 

Figure 2. (a) HE histology demonstrates a tumor island within normal brain tissue, (b) Confocal laser scanning microscopy of a GBM after sensitisation with mTHPC fluorescence localised within the tumor cells, indicating selective uptake of the sensitiser. (c) Giant tumor cell imbedded in normal brain tissue, demonstrating selective uptake into tumor cells. 

Bourges et al. studied the kinetics of polylactide (PLA) nanoparticle (NP) localization within the intraocular tissues and to evaluate their potential to release encapsulated material. Environmental scanning electron microscopy (ESEM) showed the flow of the NPs from the site of injection into the vitreous cavity and their rapid settling on the internal limiting membrane. Histology demonstrated the anatomic integrity of the injected eyes and showed no toxic effects. A mild inflammatory cell infiltrate was observed in the ciliary body 6 h after the injection and in the posterior vitreous and retina at 18-24 h. The intensity of inflammation decreased markedly by 48 h. Confocal and fluorescence microscopy and immunohistochemistry showed that a transretinal movement of the NPs was... 

Endoscopy is helpful for the diagnosis of PMC by showing typical raised yeilowish-TAhite plaques separated by areas of normal mucosa, oedema or erythema (MEGiBOwet al. 1984). The plaques usually have a thickness of 2-10 mm. These plaques can be larger,extended, and are adherent to the mucosa (Ros et aL 1996). Epithelial necrosis, infiltration of the lamina propria with polymorphonuclear cells, and eosinophilic exudates are histologically demonstrated. The "pseudomembrane is composed of cellular debris, fibrin, mucous, and polymorphonuclear cells (Hamrick et al. 1989). 

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