Hippocampus decarboxylase

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V-arachidonoyl-dopamine (NADA, 27) is an endogenous capsaicin-like substance in mammalian nervous tissues. NADA activates cannabinoid CB, receptors, but not dopamine D1 and D2 receptors (Bezuglov et al., 2001 Bisogno et al., 2000). NADA occurs in nervous tissues, with the highest concentrations being found in the striatum, hippocampus, and cerebellum and the lowest concentrations in the dorsal root ganglion (Chu et al., 2003). Proposed mechanisms of NADA biosynthesis include the condensation of AA with tyrosine and the subsequent conversion of A-arachidonoyl-tyrosine to NADA by tyrosine hydroxylase and L-aromatic amino acid decarboxylase. 

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