Highly purified insulin

Highly purified insulins insulin purified by gel filtration and ion-exchange chromatography... 

For therapy of local lumps, extravasation, etc., one should first seek to improve the injection technique. Substitution with highly purified insulin is recommended. Injection with purified insulin into the affected area may speed up resorption of the lumps. Lipodystrophy or lipoa-trophy improve after switching to highly purified human or insulin lispro. Lipohypertrophy, on the other hand, often fails to respond to changes in the insulin regimen (161). Varying the injection site may help, but differences in absorption rate then have to be taken into account. 

Insulin Preparations. The various commercially available insulin preparations are listed in Table 2.5-7. Amorphous insulin was the first form made available for clinical use. Further purification afforded crystalline insulin, which is now commonly called "regular insulin." Insulin injection. USP. is made from zinc insulin cry.stals. For some time, regular insulin. solutions have been prepared at a pH of 2.8 to 3.S if the pH were increased above the acidic range, particles would be formed. More highly purified insulin, however, can be maintained in solution over a wider pH range, even when unbuffered. Neutral insulin solutions have... 

Lipoatrophy and lipohypertrophy were the most frequently reported local complications of conventional insulin therapy. Early reports after the introduction of highly purified insulins suggested a reduction in the... 

The highly purified insulins, such as the MC insulins, are becoming more widely used. Devlin (3 ) reported that of 42 newly diagnosed diabetic patients, treated with MC insulin for 1—4 years, only 19% had detectable antibodies as compared to 82% of 45 patients treated with mixed porcine/bovine insulin. The antibody level fluctuated during the observation period. This is in contrast to an earUer communication of Yue and Turtle (4 ) who reported a significant antibody production to MC insulin in 3 out of 7 patients. 

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