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High throughput induction assay

Overall Evaluation of High-Throughput Induction Assays... [Pg.179]

LC/MS/MS with selected reaction monitoring (SRM) offers a fast and simple means to analyze biological matrices, which is a key factor in high-throughput CYP inhibition screens using liver microsomes. Potentially, the LC/MS/MS technique is suitable for analyses of cocktail substrates in other in vitro drug metabolism evaluations such as CYP induction/activation assays, rapid analysis of pooled liver microsomes, rapid reaction phenotyping of tissue (hepatic and extrahepatic) samples, as well as evaluation of hepatocytes/tissue slice CYP activity. ° ... [Pg.427]

Surry DD, McAllister G, Meneses-Lorente G, et al. High-throughput ribonuclease protection assay for the determination of CYP3A mRNA induction in cultured rat hepatocytes. Xenobiotica 1999 29 827-838. [Pg.228]

See other pages where High throughput induction assay is mentioned: [Pg.178]    [Pg.97]    [Pg.81]    [Pg.207]    [Pg.124]    [Pg.205]    [Pg.179]    [Pg.179]    [Pg.259]    [Pg.127]    [Pg.531]    [Pg.533]    [Pg.3150]    [Pg.281]    [Pg.19]    [Pg.320]    [Pg.1306]    [Pg.79]    [Pg.399]    [Pg.361]    [Pg.108]    [Pg.460]    [Pg.125]    [Pg.278]    [Pg.116]    [Pg.64]    [Pg.24]    [Pg.307]    [Pg.155]    [Pg.131]    [Pg.392]    [Pg.382]    [Pg.392]    [Pg.394]   
See also in sourсe #XX -- [ Pg.179 ]



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