High-Throughput Experimentation Approach

On the basis of existing knowledge, some general conclusions can be drawn  

From these considerations, the synthesis of silsesquioxanes was optimised, by means of HTE, as a function of the activity of the catalysts obtained after titanium coordination to the silsesquioxane structures. Therefore, this approach aimed at producing any incompletely condensed silsesquioxane that would result in active catalysts after titanium coordination rather than a specific structure (like silsesquioxane ulhS). The epoxidation of 1-octene with tert-butyl hydroperoxide (TBHP) as the oxidant was chosen as test reaction for the activity of the catalysts [26]. 

Experiments were performed on an automated parallel synthesis workstation coupled with a personal computer supplied with software enabling the workstation to be programmed. Samples were prepared in a rack containing a 6x4 array of glass tubes. Catalytic activities were measured by means of gas chromatography. The reported activities are the averages of the results from different experiments. 

The first step of this screening was to decide which parameter space had to be screened. It was hypothesised that the solvent and the R group have the most relevant role among the parameters influencing the hydrolytic condensation of organosilanes [39]. Therefore, the parameter space was defined by the combination 

The epoxidation activity of the titanium catalysts, as a function of the different solvents and R groups varied in the synthesis of the silsesquioxanes precursors, is reported in Fig. 9.2. Values are normalised to the activity of the complex obtained by reacting TifOPr1 with the pure cyclopentyl silsesquioxane 7fc3 in THF. The results show some general trends  

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Combinatorial chemistry, 7 380-434 8 400—401 13 283-284. See also High-throughput experimentation applications, 7 381-383 commercial environment, 7 387-389 methodology, 7 383-387 microwaves in, 16 548-552 nomenclature, 7 380 polymers, 7 405—413 Combinatorial libraries, 12 515-517 Combinatorial methods, 7 380 Combinatorial optimization approach, in computer-aided molecular design, 26 1037... 

High-Throughput Experimentation and Combinatorial Approaches in Catalysis... 

SYNTHETIC APPROACHES FOR HIGH-THROUGHPUT EXPERIMENTATION AND COMBINATORIAL CHEMISTRY... 

Zhang H, Marin V, Fijten MWM, Schubert US (2004) High-throughput experimentation in atom-transfer radical polymerization a general approach toward a directed design and understanding of optimal catalytic systems. J Polym Sci Part A Polym Chem 42 1876-1885... 

During the last six years several high-throughput proteomics approaches have been published, in what is certainly only the first wave of applications. The current panoply of experimental procedures is discussed in several reviews [7-9]. Traditional... 

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