High-throughput ADME

Hornig, M., Mamt, A. COSMOfrag a novel tool for high-throughput ADME property prediction and similarity... 

Keseruu, G. M. and Molnar, L., METAPRINT a metabolic fingerprint. Application to cassette design for high-throughput ADME screening, J. Chem. Inf. Comput. Sci., 2002, 42, 437-444. 

The advent of automation techniques moved high-throughput ADME screening from individual test tube to multiwell plates. The use of 96- and 384-well plates produced a data explosion and the need to capture, store, and mine data so that it can be used effectively. A database for storing and... 

Herbst et al.2 described automated high-throughput ADME/Tox profiling for optimization of preclinical candidates, a Profiling Toolkit enables researchers to request profiles, track progress, receive notification when the requests have been filled, and view data. Automated systems and bar coding improve efficiency, help track compound and plate locations, and create audits trail of the profiling process. 

Herbst, J.J. and Dickinson, K. 2005. Automated high-throughput ADME/Tox profiling for optimization of preclinical candidate success. Am. Pharm. Rev. 8 96. 

Jenkins, K.M. et al. 2004. Automated high throughput ADME assays for metabolic stability and cytochrome P450 inhibition profiling of combinatorial libraries. J. Pharm. Biomed. Anal. 34 989. 

LGMS APPLICATION IN HIGH-THROUGHPUT ADME SCREEN... 

O Connor, D. Automated sample preparation and LC-MS for high-throughput ADME quantification. Curr Opin Drug Discov Dev 2002, 5, 52-58. 

Kassel, D. B. Applications of high-throughput ADME in drug discovery. Curr Opin Chem Biol 2004, 8, 339-345. 

Herman, J. L. (2004). Generic approach to high throughput ADME screening for lead candidate optimization. Int. J. Mass Spectrom. 238 107-117. 

Automated Data Processing Is Instrumental to Achieving High-Throughput ADME... 

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