High-pressure liquid chromatography capacity factor

Perkin Trans. 2, 2087 (1988). Solute-Sovent Interactions in Chemistry and Biology. Part 7. An Analysis of Mobile Phase Effects in High Pressure Liquid Chromatography Capacity Factors and Relationships of the Latter with Octanol-Water Partition Coefficients. 

Relationships such as Eqs. (45) and (46) have been utilized extensively in correlating solubility properties (such as gas/liquid and liquid/liquid partition coefficients), retention volumes in gas/solid chromatography, capacity factors in high-pressure liquid chromatography, etc.199 200 For instance, gas/liquid partition coefficients for each of 35 different liquid stationary phases were represented with R > 0.985.205 Other applications have been in biochemical and pharmacological areas,199 200 e.g., enzyme inhibition and pollutant effects. 

Armstrong and Nome " have shown that chromatographic methods such as high-pressure liquid chromatography (HPLC) and thin layer chromatography (TLC) can be used for determination of partition coefficients. The aqueous micellar solutions are used as the mobile phase. When the concentration of micelles in the mobile phase is increased, the retention and capacity factors of... 

In reverse phase high-pressure liquid chromatography (RP HPLC), the mobile phase is usually an aqueous-organic mixture, permitting the phenomenological theory to be applied. LePree and Cancino carried out this analysis. The composition-dependent variable is the capacity factor k, defined by eq. [8.2.51],... 

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