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High-performance liquid chromatography general characterization

In this chapter, high-performance liquid chromatography of oligomers and (high) polymers (polymer HPLC) will be briefly presented. As mentioned in Section 16.1, there exist several monographs, chapter in books, and review papers on this subject, for example [1-33], Most of them contain numerous examples of the HPLC separation and molecular characterization of particular macromolecular substances. Therefore, this chapter discusses almost exclusively the general principles of polymer HPLC and only few selected examples of practical applications will be mentioned for illustration. [Pg.452]

The purity control and the structure verification of compound collections from automated synthesis and combinatorial chemistry play an essential role in the success of medicinal chemistry programs. High performance liquid chromatography (HPLC), mass spectrometry (MS), and liquid chromatography-mass spectrometry (LC-MS) techniques are generally accepted as the most appropriate means of characterization (1,2). While these analytical methods are fast and easy to automate, they do not provide sufficient structural and quantitative data about the desired products. [Pg.123]


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See also in sourсe #XX -- [ Pg.160 ]




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