High-Field Asymmetric Waveform Ion-Mobility Spectrometry FAIMS

4 High-Field Asymmetric Waveform Ion-Mobility Spectrometry (FAIMS) 

In FAMS, the gas-phase mobility separation of ions in an electric field is achieved at atmospheric pressure [145-147], In its simplest design, the FAIMS device comprises two parallel rectangular electrodes at a uniform distance (Fig. 4.9). One of the electrodes is grounded, while at the other an asymmetrical waveform is applied. The asymmetric waveform is characterized by a significant difference in voltage in the positive and negative polarities of the waveform. FAMS nti- 

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Kolakowski, B. M., Lustig, D., and Purves, R. W. (2004). Separation and quantitation of caffeine metabolites by high-field asymmetric waveform ion mobility spectrometry (FAIMS). 

Kolakowski, B.M. Mester Z., Review of applications of high-field asymmetric waveform ion mobility spectrometry (FAIMS) and differential mobility spectrometry (DMS), Analyst 2001,132(9), 842-864. 

McCooeye, M.A. Ells, B. Barnett, D.A. Purves, R.W. Guevremont, R., Quantitation of morphine and codeine in human urine using high-field asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection, J. Anal. Toxicol. 2001, 25, 81-87. 

Gabryelski, W. Froese, K.L., Rapid and sensitive differentiation of anomers, linkage, and position isomers of disaccharides using high-field asymmetric waveform ion mobility spectrometry FAIMS, J. Am. Soc. Mass Spectrom. 2003, 14, 265-277. 

See Volume 4, Chapter 5 High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) by Randall W. Purves. 

Whereas high-field asymmetric waveform ion mobility spectrometry (FAIMS) is able to separate ions in a manner similar to IMS, the method cannot be considered an alternative to IMS in the context (elucidation of ion structure) discussed here, since electric fields employed in FAIMS are way above the low-field limit. " - However, two other newer developments, traveling-wave IMS and overtone ion mobility spectrometry (OMS), are worth mentioning here briefly. 

Robinson, E. W. Sellon, R. E. Williams, E. R. Peak deconvolution in high-field asymmetric waveform ion mobility spectrometry (FAIMS) to characterize macromolecular conformations. Int. J. Mass Spectrom. 2007, 259, 87-95. 

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