High entrapment efficiency

Solubilization of vinylpyrrolidone, acrylic acid, and A,A -methylene-bis-acrylamide in AOT-reversed micelles allowed the synthesis in situ of a cross-linked polymer with narrow size distribution confined in the micellar domain. These particles displayed high entrapment efficiency of small hydrophilic drugs and have been considered interesting drug delivery systems [239],... 

For a binary system (one polycation and one polyanion on each interaction side), CT/TPP, Calvo et al. [15] described very high entrapment efficiencies from 20 to 92 %. CT/TPP PEO or PEO/PPO polymers were co-entrapped within the final product. Nanoparticles were formed spontaneously by simple mixture of... 

Fig. 3). Calvo et al. [14] described CT-TPP nanoparticulate delivery vehicles for proteins and demonstrated high entrapment efficiencies (between 20 to 90 %). Their particles, however, dissolved at lower pH. 

Viswanathan, N. B., Thomas, P. A., Pandit, J. K., Kulkarni, M. G., and Mashelkar, R. A. (1999), Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique, J. Controlled Release, 58, 9-20. 

In another study, magnetic chitosan-alginate core-shell beads were developed for oral administration of small molecules to increase bioavailability level. The beads were found to be resistant in acidic media (stomach pH) and bioadhesive, presenting a superparamagnetic behavior and a very high entrapment efficiency [105]. 

New method to prepare HCO-10 vesicles with high entrapment efficiency... 

ET. Meng, et al. Microencapsulation of bovine hemoglobin with high bio-activity and high entrapment efficiency using a W/O/W double emulsion technique. Colloids and Surfaces B Biointerfaces, 33(3-4) 177-183, 2004. 

The biggest advantage of this flexible jet technique is the high entrapment efficiency of more than 80 %. We calculated these special features from UV-Vis measurements measuring the Aniline Blue concentration one hour after the vesicle production. The absorption of this blue dye after the destruction of the vesicles by adding Triton X 100 was taken as the reference and compared to the absorption before the destruction of the vesicular stractures. 

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