N-Hydroxymethyl-chloracetamide

Generally the activity of formaldehyde releasing compounds is reduced in alkaline media containing ammonia, because of the formation of inactive hexamethylene tetramine (3.3.1.). In the case of MCA, however, the hexamethylenetetramine formed reacts with MCA or CA to give quaternary hexaminium salts (3.3.5. or 3.3.6) which are effective, as they release formaldehyde widely independent of pH (see 3.3). 

However, altogether the importance of MCA as a preservative for water-based functional fluids is on the decline, as there is no great hope of the toxicological profile. 

Chemical name Chemical formula Structural formula Molecular mass CAS-No. 

Compared with MCA (3.4.1.) 2,2,3-trichloro-N-hydroxymethylpropionamide does not exhibit special activity. However, because of its excellent solubility properties - soluble not only in water but in non-polar solvents, too- it has been characterised by Paulus et al., 1967 as an active ingredient which is highly appropriated as a preservative for oil-based lubricoolants. 

Microbicide group (substance class) Chemical name 

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N-(N -hydroxymethyl-)carbamoylmethyl-hexaminium chloride is compared with other quaternary hexaminium salts of superior efficacy as the starting material for quaternizing hexamethylenetetramine in this case is a formaldehyde releasing compound, too, namely N-hydroxymethyl-chloracetamide (3.4.1.) - Applications as described under 3.3.2. - 3.3.4. - Addition rates 0.05-0.2%. 

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