Hexamethylene bis

Ghlorhexidine Gluconate. Chlorhexidine gluconate [18472-51 -0] (l,l -hexamethylene bis[5-(p-chlorophenyl) biguanide] di-D-gluconate) is used as an antimicrobial against both aerobic and anaerobic bacteria ia the oral cavity. It is used as a therapeutic supplement ia the treatment of gingivitis, periodontal disease, and dental caries. A mouth riase form is available as a 0.12 wt% aqueous solution (288). 

Included among other differentiating cell lines which have been established in culture, is the human promyelocytic cell line HL-60, which differentiates into more mature myeloid cells upon treatment with retinoic acid and prostaglandin E] (PGEi). Friend erythroleukemia cells differentiate into hemoglobin-producing cells when treated with either dimethyl sulfoxide, or hexamethylene bis-acetamide. 

Chemicals like polyorthoaminophenol, diphenylamine in small amounts have been found to decrease the yield of cross-linking [388]. The tensile strength of the carbon black-filled polychloroprene compounds has been found to be comparable to the conventional thermally cured one. The physical properties [389] have been observed to improve on adding cross-linking promoters like A,A -hexamethylene-bis-methacrylamide into the polymer matrix. 

The presence of sodium hexamethylene bis-thiosulphate results in the formation of hybrid polysulphidic/hexamethylene bonds. The polysulphidic portion of these hybrid bonds reverts to monosulphidic during reversion but stability is achieved by the presence of the hexamethylene. 

The original process used aqueous tetraethylammonium ethylsulfate as the electrolyte, a lead cathode, and a lead-silver alloy anode. The Mark II process, commercialized in the mid-1970s, uses an emulsion of acrylonitrile in aqueous sodium phosphate containing a salt of the hexamethylene-bis-(ethyldibutylammonium) cation. The process was invented in 1959 by M. M. Baizer at Monsanto Corporation, St. Louis, MO. It was commercialized in 1965 and has been continuously improved ever since. The process is also operated in Japan by Asahi Chemical Industry Company. In 1990, the world production of adiponitrile by this process was over 200,000 tonnes per year. 

Procedure 2 Synthesis of a Polyester Containing Di(hydroxyethyl)hexamethylene Bis-carbamate under Solvent-free Conditions... 

A flange flask was loaded with 1,6-hexanediol (50.37 g 0.43 mol), dihydroxyethyl hexamethylene bis-carbamate (15.23 g, 0.05 mol) and diphenyl ether (50 % equal weight) and was heated to 80 °C until a solution was obtained. 

Irradiation of carbon-black-reinforced polychloroprene compounds produced a maximum tensile strength of 20 MPa (2,900 psi) at a dose of 20 Mrad (200 kGy), which is a value obtained typically from chemically cured compounds. The addition of 20 phr of N,N -hexamethylene-bis methacrylamide as a prorad in the above compound produced a tensile strength of 18 MPa (2,610 psi) at a dose of 7 Mrad (70 kGy). Further addition of 6 phr of hexachlo-roethane caused the deterioration of the tensile strength by 50% at the 7 Mrad (70 kGy) dose. ... 

A mixture of 16 g (0.09 mole) l,l -hexamethylene-bis(3-cyanoguanidine) and 20 d (0.12 mole) 2-ethylhexylamine hydrochloride is heated at 150-155°C for 3 hours. The mixture is cooled and the product is dissolved in 75 ml of hot water. The solution is treated with activated charcoal. l,l -Hexamethylene-bis-(5-(ethylhexyl)biguanide) is recrystalluized from methanol-ether, melting point 220.6-223.4°C. 

After having been cooled it is washed three times in water, three times in a 5% solution of caustic soda, and then another three times in water. The solution in xylene is dried over sodium sulfate and the xylene is completely distilled off in vacuo. Thus 11.0 parts of hexamethylene-bis-(N-methylcarbamic acid-3-pyridyl ester) are obtained. 

To a solution of 13.2 g (0.054 mole) of 9-bromofluorene in 200 ml of acetonitrile was added 3.1 g (0.018 mole) of l,6-bis(dimethylamino)hexane. Heat was evolved and solid began to precipitate immediately. After the initial reaction had subsided the mixture was refluxed for 3.5 h on a steam bath. The solid was collected and recrystallized three times from propanol to give 10.66 g (89% of the theoretical yield based on alkylenediamine) of hexamethylene bis(9-fluorenyldimethylammonium) dibromide, as white crystals melting at 188°-189°C. 

A mixture of 4.18 g (0.02 mole) of 2-dimethylaminofluorene and 1.22 g (0.005 mole) of 1,6-dibromohexane was heated at 115°C for 24 h, after which time 10 ml of dry dioxane was added and the mixture refluxed for an additional 37 h. The solid was filtered off washed with hot acetonitrile and twice recrystallized from propanol to give 0.45 g of hexamethylene bis(2-fluorenyldimethylammonium) dibromide, melting at 220°-222°C. 

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