Hexahydrobenzo

Cyclohexylcarbinol has been prepared by the reduction of ethyl hexahydrobenzoate with sodium and alcohol, and by... 

On hydrogenation, delphinine forms hexahydrodelphinine, CgaHgjOgN, m.p. 192-3°, by reduction of the benzoyl radical, hexahydrobenzoic acid replacing benzoic acid as a product of hydrolysis. 

Reaction of trans-1,2-cyclohexanediol with para-formaldehyde in the presence of Indion 130 as catalyst to yield the corresponding cyclic formal has been successfully carried out (Matkar and Sharma, 1995). A conversion of 52% was realized with 70% selectivity towards cyclohexanediol formal the other side products are rrans-hexahydrobenzo-l,3,5-trioxypin, di(tra i -2-hydroxycyclo-hexyloxy) methane. 

Hexahydrobenzene, c347 Hexahydrobenzoic acid, c353 Hexahydrobenzylamine, c362 Hexahydrophthalic acid, c356 Hexahydropyridine, pi80 Hexamethylenediamine, h53 Hexamethylene diisocyanate, d461... 

XIX), methyl 2-fluoromethyl-3 6-endomethylene-A -tetrahydro-benzoate (XX) and methyl 2 fluoromethyl 3 6 endomethylene hexahydrobenzoate (XXI). 

Uses Manufacture of adipic acid, hexahydrobenzoic acid, maleic acid, 1,3-butadiene catalyst solvent oil extraction component of coal tar stabilizer for high octane gasoline organic synthesis. 

Dihydrobenzopyran (chromane) and its methyl homologs were reduced by lithium in ethylamine and dimethylamine to 3,4,5,6,7,8-hexahydrobenzo-pyrans in 84.5% yields [424. ... 

Hydrogenation over nickel catalyst at high temperatures and pressures affects aromatic rings. Over Urushibara nickel at 106-150° and 54atm, ethyl benzoate gave ethyl hexahydrobenzoate in 82% yield [48]. 

Estradiol, 161 Estradiol benzoate, 162 Estradiol cypionate, 162 Estradiol dipropionate, 162 Estradiol hexahydrobenzoate, 162 Estradiol valerate, 162 Estrogenic activity, 100 Estrogens, 100, 160 antagonists,104 discovery, 155 impeded, 104 Estrone, 156, 161... 

The enamine-immonium cation system of 9,10-dimethoxy-l,2,3,4-6,7-hexahydrobenzo[a]quinolizinium salt [166]. 

The cis and trans isomers of ethyl-2,3-dihydrobenzo[i>]thiophen-2,3-ylene acetate (30)228 and cis -and fr]thiophene 27 have been synthesized. Addition of chlorine to the 5,6-double bond of 31 affords a mixture of cis- and[Pg.206]

When 3-mercaptocyclohexanone condenses with dichloroacet-aldehyde or chloroacetaldehyde in the presence of a catalytic quantity of acid (e.g., p-toluenesulfonic acid), simultaneous cyclization occurs to give 4,5,6,7-tetrahydrobenzo[6]thiophen-4-one (see Section VI, B, 4) and 2,4,5,6,7,7a-hexahydrobenzo[6]thiophen-4-one (see Section... 

By the same general method, M-butyl bromide gives m-valeric acid in 64-65 per cent yield, bromobenzene gives benzoic acid in 70-71 per cent yield, and cyclohexyl bromide gives hexahydrobenzoic acid in 68 per cent yield. 

Hexahydrobenzoic acid, c317 Hexahydrobenzylamine, c324 Hexahydrophthalic acid, c320 Hexahydropyridine, pi 83 Hexamethylenediamine, h56 Hexamethylene diisocyanate, d410... 

Irradiation of 720a in MeOH saturated with 2-butyne affords 2,3-dihy-drothiophene-3-acetate 721, 3-thiabicyclo[3.1.0]hexane 722, and 2,3-dihy-drothiophene-3-carboxylate 723 in a 1 1 1 ratio. From 720b, a 1 1 mixture of trans-fused 3a,4,5,6,7,7a-hexahydrobenzo[b]thiophene 724 and of 2,3-dihy-drothiophene-3-carboxylate 725 is formed. 

Taira, K. Lai, K. Gorenstein, D. G. Stereoelec-tronic effects in the conformation and hydrolysis of epimeric (4aa, 8a/ )-hexahydrobenzo-2-(p-nitrophenoxy)-2-oxo-l,3,22.5dioxaphosphori-... 

The synthesis of S-keto-hexahydrobenzoic acid further illustrates the use of cyanacetic ester,17... 

Similar results were obtained with enamines of acyclic ketones such as desoxybenzoin. Nitrostyrene gave only the less substituted mono-alkylated enamine and hence the / -nitro-a-phenylethyl ketone on hydrolysis117. Surprisingly 2-nitropropene gives mainly the tetrasubstituted cyclohexanone enamine106. A hexahydrobenzo-l,2-oxazine-7V-oxide (55) was isolated at low temperatures (in 80% yield) which rearranged at room temperature to a mixture of alkylated enamine isomers107 (Scheme 39). 

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