Hexafluorine® solutions calcium gluconate

With this model of human skin explant, after the validation of the experimental bum, the challenge was to compare various methods for washing HF bums. We selected two of them water washing followed by application of a 2.5 % calcium gluconate (CaG) cutaneous gel with topical application versus HEXAFLUORINE solution as a specific washing solution, which, due to its anti-acid and fluoride ion-chelating properties, matches the two dangers of HF corrosion and toxicity. 

Figure 4.66a, b show histological aspects at 24 h without any washing, compared to aspects after water washing and calcium gluconate (Fig. 4.67a, b) at the same time and HEXAFLUORINE solution (Fig. 4.68a, b). 

Calcium gluconate acts like a fluoride ion chelator. But its chelating constant is weaker than that of the HEXAFLUORINE solution. 

This experiment also shows that an efficient washing can be achieved by following the protocol of HEXAFLUORINE solution used within a minute. Beyond the standard protocol, the use of calcium gluconate after washing with 14EXAFLUORINE solution will be an interesting additional care under the responsibihty of a medical staff. 

Using the Dunser s table (Table 4.14 above), five accidents could have presented lethal risk among the 26 skin cases reports to hydrofluoric acid, but no sign of systemic effect was observed. Decontamination with HEXAFLUORINE solution was immediately performed in most of the cases and followed by calcium gluconate, if needed. No surgical treatment or long hospitalization was necessary, except with a delayed use, where the HF bum has already developed. 

HEXAFLUORINE solution, apply a treatment based on a chelating fluoride antidote such as calcium gluconate. 

Now, when patients are coming in hours of accident, the decontamination of the lesions with HEXAFLUORINE solution permits to avoid intra-arterial infusion of calcium gluconate solution with its potential complications. Nevertheless, we continue to apply calcium gluconate gel during 1 or 2 days. 

HF vapor [266] Right cheek HEXAFLUORINE solution Slight painless erythema. Application the next day with calcium gluconate gel, no lost work time... 

Rinsing of 20 s, 25 gL, 2.5% HF burns with different fluids (a) no rinsing, (b) rinsing with tap water for 15 min, (c) rinsing with calcium gluconate 2% for 15 min, and (d) rinsing with Anti HF solution (Hexafluorine ) for 15 min. 

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