Hexachlorobutadiene, HCBD

Toxicology. Hexachlorobutadiene (HCBD) causes kidney damage including renal cancer in experimental animals it also produces central nervous system effects and causes hepatic disorders at very high concentrations. 

Berndt WO, Mehendale HM. 1979. Effects of hexachlorobutadiene (HCBD) on renal function and renal organic ion transport in the rat. Toxicology 14 55-65. 

EPA. 1976. An ecological study of hexachlorobutadiene (HCBD). Washington, DC U.S. Environmental Protection Agency, Office of Toxic Substances. EPA/560/6-76-010. 

A variety of halogenated alkanes and alkenes such as hexachlorobutadiene, chlorotrifluoro-ethylene, tetrafluoroethylene, and trichloroethylene (Fig. 7.28) are nephrotoxic. Studies have shown that metabolic activation is necessary for toxicity, but this does not involve cytochromes P-450. Thus, hexachlorobutadiene (HCBD) is a potent nephrotoxin in a variety of mammalian species, and the kidney is the major target. 

Thus, hexachlorobutadiene (HCBD) is a potent nephrotoxin in a variety of mammalian species, and the kidney is the major target. 

A characteristic of many modern integrated productions units is their flexibility in terms of balance of products, which are separated from each other, and purified, by distillation. The lights fraction from one product will therefore consist largely of a mixture of several other products in the class, and so need not be separately considered. The heavies fractions contain a number of highly chlorinated aliphatic compounds of chain lengths C2-C4, and higher, of which the most common and characteristic is hexachlorobutadiene (HCBD), and also hexachlorobenzene (HCB). Estimates suggest a world output of 10,000 tons of HCBD in the heavy ends of all the chlorination processes, with lesser quantities of pentachlorobuta-diene, and penta and hexachlorethane. 

Synonyms AI3-05773 BRN 1766570 C 46 CCRIS 326 Dolen-pur EINECS 201-765-5 GP-40-66 120 HCBD Hexachlorbutadiene 1,1,2,3,4,4-Hexachlorobutadiene 1,3-Hexachloro-butadiene Hexachloro-1,3-butadiene 1,1,2,3,4,4-Hexachloro-l,3-butadiene NSC 3701 Per-chlorobutadiene RCRA waste number U128 UN 2279. 

Hexachlorobutadiene, also known as HCBD, perchlorobutadiene, or Dolen-Pur, is a colorless liquid. It does not evaporate or bum easily. Hexachlorobutadiene has a turpentine-like odor. Most people will begin to smell a mild to pungent odor if the compound is present in air at 1 part hexachlorobutadiene per million parts of air (ppm). It is not known how it tastes or at what level people can taste it. 

Hb hemoglobin as in Hb402, which is four subunits with one molecule of oxygen bound. HCBD hexachlorobutadiene. 

Synonyms/Trade Names HCBD Hexachloro-1,3-butadiene 1,3-Hexachlorobutadiene Perchlorobutadiene... 

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