Heterocyclic Drugs

For convenience, the following sections are grouped, where possible but with flexibility, according to the natural neurotransmitter or enzyme to which the drugs relate and may include central and peripheral actions. A separate section on CNS-specific drags with more complex mechanisms is included later. Later major sections, for example infection and cancer, are, of necessity, related to disease areas. 

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Sleep and its modulation by N- and N,0-heterocyclic drugs that affect y-aminobutyric acid (GABA) receptor function 99AG(E)2852. 

QSAR and Molecular Modeling Studies in Heterocyclic Drugs II... 

Duchowicz PR, Castro EA, Toropov AA, Benfenati E (2006) Applications of Flexible Molecular Descriptors in the QSPR-QSAR Study of Heterocyclic Drugs. 3 1-38... 

Ponnuswamy MN, Gromiha MM, Sony SMM, Saraboji K (2006) Conformational Aspects and Interaction Studies of Heterocyclic Drugs. 3 81-147 Prabhakar YS, Solomon VR, Gupta MK, Katti SB (2006) QSAR Studies on Thiazolidines A Biologically Privileged Scaffold. 4 161-248... 

An effective treatment is griseofulvin (49). It is administered orally at 10 mg kg-1. The isothiazole etisazole (50) can also be used to treat dermal fungal infections. Other heterocyclic drugs with antifungal potential have been reviewed (78MI10800). 

Although the structures of heterocyclic drugs often look complicated, their synthesis is usually... 

Overdoses of amoxapine are characterized by severe neurotoxicity, with seizures that are difficult to control. Overdoses of maprotiline also have a tendency to cause seizures as well as cardiotoxicity. Overdoses of the other heterocyclic drugs appear to create only minor problems and can usually be managed with purely supportive measures. For example, in one recorded case even 11 g of nefazodone failed to cause serious injury. 

Combinatorial synthesis and screening of heterocyclic, drug-like scaffold libraries... 

QSAR and Molecular Modeling Studies in Heterocyclic Drugs I Volume Editor S. P. Gupta Volume 3,2006... 

B. Feibush, A. Figueroa, R. Charles, K. Onan, P. Feibush, and B. L. Karger, Chiral separation of heterocyclic drugs by HPLC Solute-stationary phase base-pair interactions,/. Am. Chem. Soc. 108 (1986), 3310. 

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