Heterocyclic aromatic amines Subject

An appendix systematically lists references to reactions of dialkylalkoxy-malonates with amines, including not only the common aliphatic and aromatic amines, but also a very wide variety of heterocyclic amines classified according to ring system. The appendix also provides systematic references to the different ring systems obtained by ring closure of the dialkylaminomethylenemalonates. The appendix should be used in conjunction with the subject index a separate subject index is provided for this monograph volume. 

A vast array of piperidine containing cores, both natural and synthetic, are of biological and medicinal interest. These heterocyclic scaffolds have been the subjects of considerable synthetic efforts, especially for the construction of optically active compounds. In this context, Khan et al. reported a catalytic bromodi-methylsulfonium bromide (BDMS) three-component reaction of 1,3-dicarbonyls with aromatic aldehydes and aromatic amines for a facile access to highly functionalized piperidines (Scheme 24) [104]. This strategy is an interesting illustration of... 

The range of organic compounds which have been subject to the Simons process is wide and includes aliphatic and aromatic hydrocarbons, halocarbons, ethers, aliphatic and aromatic amines, heterocyclics, thiols, alkyl sulphonic and carboxylic acids, and their derivatives, among others. 

Direct UV spectrophotometric detection of aromatic amines from azo dye reduction in textile industry wastewaters and electrophoretic methods for biogenic and aromatic amines have been the subject of recent reviews. In addition, environmental applications of mutagenic heterocyclic amines... 

Like ruthenium, amines coordinated to osmium in higher oxidation states such as Os(IV) are readily deprotonated, as in [Os(en) (NHCH2CH2NH2)]2+ [111614-75-6]. This complex is subject to oxidative dehydrogenation to form an imine complex (105). An unusual Os(IV) hydride, [OsH2(en)J2+ [57345-94-5] has been isolated and characterized. The complexes of aromatic heterocyclic amines such as pyridine, bipyridine, phenanthroline, and terpyridine are similar to those of ruthenium. Examples include [Os(bipy )3 ]2+ [23648-06-8], [Os(bipy)2acac] [47691-08-7],... 

Topics which have formed the subjects of reviews this year include theoretical studies of the photochemistry of thiiranes, photoaddition of amines to aryl olefins and arenes, the synthesis of heterocyclic compounds, photoamination directed towards the synthesis of heterocycles, selective addition of organic dichalcogenides to carbon-carbon unsaturated bonds, photocyclisation mechanisms of c/5-stilbene analogues, synthetic utility of the photocyclisation of aryl-and heteroarylpropenoic acids, photochromic diarylethenes, spiropyrans, cy-clophanes, and polycondensed aromatics," photochromic organic media, photophysics and photochemistry of P-carbolines, and the photochemical synthesis of macrocycles.Chirality switching by light has also been described. ... 

The Chichibabin reaction with imidazoles has been the subject of extensive study in the U.S.S.R. (82CHE1221). Criteria for successful amination require that the imidazole ring be condensed with an aromatic system at the 4-and 5-positions, and that the pyrrole nitrogen be substituted (Scheme 72) (73CHE88). Another requirement is that the heterocycle must have a pK, of at least 4.3 for heterogeneous aminations. The parent compound, imidazole, substituted in the 1-position, does not undergo the Chichibabin reaction. Even substituted imidazoles such as phenanthro[9,10-d] imidazole (204) do not aminate (73CHE88). 

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