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1,7-Heptanedicarboxylic acid

Azelaic acid is a naturally occurring dicarboxyl-ic acid (1,7-heptanedicarboxylic acid) that has demonstrated beneficial therapeutic effects in the treatment of acne and several disorders of hyperpigmentation [48]. There are minimal effects on normally pigmented human skin, freckles, senile lentigines, and nevi. The cytotoxic and antiproliferative effects of azelaic acid may be mediated via inhibition of mitochondrial ox-idoreductase activity and DNA synthesis. Disturbance of tyrosinase synthesis by azelaic acid may also influence its therapeutic effects. Azelaic acid can be used as a hypopigmenting agent in patients sensitive to hydroquinone. [Pg.169]

Azelaic acid is a non-phenolic derivative (1,7-heptanedicarboxylic acid) used at concentration of 10-20% twice a day to treat melasma with minimal side effects (allergic reactions). It acts to disturb the tyrosinase synthesis and can be used as a bleaching agent in patients sensitive to hydroquinone. Better results are obtained if a glycolic acid cream is applied sequentially to azelaic acid treatment. [Pg.153]

Therapeutic Function Antiacne, Depigmentor Chemical Name 1,7-Heptanedicarboxylic acid... [Pg.486]

CAS 123-99-9 EINECS/ELINCS 204-669-1 Synonyms Anchoic acid Dicarboxylic acid C9 Heptanedicarboxylic acid 1,7-Heptanedicarboxylic acid Lepargylic acid Nonanedioic acid 1,7-Nonanedioic acid Empirical CgHisO,... [Pg.983]

Heptanedicarboxylic acid 1,7-Heptanedicarboxylic acid. See Azelaic acid 2,3-Heptanedione... [Pg.1980]

Azelaic Acid n (nonanedioic acid, 1,7-heptanedicarboxylic acid) H00C(CH2)7C00H. A yellowish to white crystalline powder, derived from a fatty acid such as oleic acid by oxidation with ozone. It is an intermediate used in the production of plasticizers, polyamides, and alkyd resins. Acid value, 595.5 mol wt, 188.2 mp, 106°C bp, 237°C/15 mmHg ((2001) Merck index, 13th edn. Merck and Company, Whitehouse Station, Nl). For plasticizers derived from azelaic acid. See Dicyclohexyl—, Di(2-Ethylbutyl)—, Di... [Pg.58]

DOZ (DEHZ), (esters of 1,7-heptanedicarboxylic acid—a nine-carbon aliphatic acid) dioctyl azelate (di-2-ethylhexyl azelate)... [Pg.80]

Azelaic acid or 1,7-heptanedicarboxylic acid is a saturated dicarboxyhc acid naturally found in wheat, barley, and rye. It is active in a concentration of 20% in topical products used in a number of skin conditions, mainly acne. Azelaic acid is used to treat mild to moderate acne, i.e., both comedonal acne and inflammatory acne. It works in... [Pg.11]

See other pages where 1,7-Heptanedicarboxylic acid is mentioned: [Pg.639]    [Pg.339]    [Pg.318]    [Pg.365]    [Pg.462]    [Pg.639]    [Pg.339]    [Pg.318]    [Pg.365]    [Pg.462]   
See also in sourсe #XX -- [ Pg.51 ]



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