Bromo heptane

Heptane, 1-bromo-2-fluoro, 46,10 Heptanoic acid, 2-fluoro-, 46,37 2-Heptanone, 47, 89 4-Heptanone, 47, 75 Heptanoyl fluoride, 46, 6... 

Heneicosanoic acid, 60, 13 Heptadecanoic acid, 60, 13 Heptane, 1-bromo- [629-04-9], 61, 59 Heptanoic acid, 60, 13 2-HEPTYL-2-CYCLOHEXENONE, 61, 59... 

D-AniMC acid (8) Benzoic acid, 2-methoxy- (9) (579-75-9) l-Bmnioheptanc Heptane, 1-bromo- (8, 9) (629-04-9) ( yclt)hcxdnc-1,3-dionc 1,3-Cyclohexanedione (8, 9) (504-02-9)... 

S-(2a,5a,6b])-6-Bromo-3,3-dimethyl-7-oxo-4-thia-l-azabicyclo [3.2.0]heptane-2-carboxyhc acid... 

Penam P-Lactamase Inhibitors. Penam is the trivial name given derivatives of the penicillin nucleus (31) the chemical name of which is 4-thia-l-a2abicyclo[3.2.0]heptane. Table 6 gives activity data for a diverse group of penams. The report that 6-P-bromopeniciU.anic acid [26631-90-3] [2(3)-(2a,5a,6P)]-6-bromo-3,3-dimethyl-7-oxo-4-thia-l-a2abicyclo[3.2.0]heptane-2-carboxyhc acid, (31, R = Br, R =H, R" = R " = CH3) a potent... 

Ethylene, bromo-(8) Ethene, bromo- (9) (593-50-2) Bicyclo[3.2.0]heptan-2-ol, 3,3-dimethyl- (9) (71221-67-5) Bis(copper(I) trif1uoromethanesulfonate)benzene complex Copper,... 

The SET mechanism is chiefly found where X = I or NO2 (see 10-104). A closely related mechanism, the SrnE takes place with aromatic substrates (Chapter 13). In that mechanism the initial attack is by an electron donor, rather than a nucleophile. The Srn 1 mechanism has also been invoked for reactions of enolate anions with 2-iodobicyclo[4.1.0]heptane. An example is the reaction of l-iodobicyclo[2.2.1]-heptane (15) with NaSnMe3 or LiPPh2, and some other nucleophiles, to give the substitution product. Another is the reaction of bromo 4-bromoacetophenone (16) with Bu4NBr in cumene. " The two mechanisms, Sn2 versus SET have been compared and contrasted. There are also reactions where it is reported that radical, carbanion, and carbene pathways occur simultaneously. ... 

In alkaline solution, 3-bromo-2,2-bis(bromomethyl)propanol undergoes successive loss of bromide to produce 2,6-dioxaspiro(3,3)-heptane (Ezra et al. 2005) (Figure 1.25). 

We developed a convenient synthesis of 3-cyclopentenyl hydroperoxide via hydro-boration and autoxidation of cyclopentadiene, and bromination proceeded smoothly to afford 32 40). Ring closure with silver trifluoroacetate (Eq. 26) afforded a 5-bromo-2,3-dioxabicyclo[2.2.1]heptane 34 (6%) and a 5-trifluoroacetoxy-2,3-dioxabicyclo-[2.2.1]heptane 35 (14%), and it was shown independently that 34 is rapidly converted into 35 by reaction with Ag02CCF3. To avoid the trifluoroacetate bromide substitution that accompanies and competes with the dioxabicyclization, 32 was treated with silver oxide and this slowly yielded an isomeric 5-bromo-peroxide 33 (42 %) (Eq. 26). 

It has been shown (820025) by means of 0-NMR spectroscopy that 2-ej o-bromo-7,7-dichloro-3-endo-hydroxybicyclo[3.2.0]heptan-6-one (7B see Section I,B) exists in OOOI3 solution as an equimolecular mixture of... 

A camphor-based 3-acyl-2-oxazolidinone has also been used for diastereoselective alkylations66. The A-acylated auxiliary 18 is prepared in three steps from 7,7-dimethyl-2-oxobicy-clo[2.2.1]heptane-l-carboxylic acid (ketopinic acid, 17)67. Deprotonation by lithium diiso-propylamide in tetrahydrofuran at — 78 °C and subsequent alkylation with activated halides [(bromo- or (iodomethyl)benzene, 3-bromo- or 3-iodopropene] furnished moderate to good yields of alkylation products in high diastereomeric ratios (>97 3 by H NMR). With added hexamethylphosphoric triamide the alkylation yields are increased and bromoalkanes also give satisfactory yields. The diastereomeric ratios are, however, much lower (d.r. 70 30 to 85 15)67. 

Using h NMR spectroscopy the complex-formation equihbria between halothane (2-bromo-2-chloro-l,l,l-trifluoroethane) and methyl tert-butyl ether or tetrahydrofu-ran in various inert solvents (hexane, heptane, decane, cyclohexane) were measured as a function of temperature (Tkadlecova et al., 1995). 

Under biphase conditons (in dry dioxane) the activity of 46 for the reaction of 1-bromo-heptane with sodium phenoxide decreased with an increase in the length of aliphatic chains. Under triphase conditions, however, only catalyst 46 with n-octyl groups was active for chloride displacement reactions, and catalysts with groups smaller than n-butyl showed no activity 165). Polyacrylamides 46 with short aliphatic chains are too hydrophilic to act as catalysts under triphase conditions. Similar behavior has been observed for ammonium salts supported on dextran 95). 

The solvolysis of 7,7-dibromo-bicyclo[4.1.0]heptane in methanol in the presence of silver perchlorate leads to ( -2-bromo-3-methoxycyeloheptene [172, 173]. A more detailed study of this reaction — having been performed by Ito in 1986 [174] — has revealed that the stereochemical result of the solvolysis depends on the length of the polymethylene chain in these bicyclic dihalides. For the lower homologs (n = 2 to 4) it is the ( )-isomer XIII that is produced, whereas for the more extended systems (n = 5 to 8) the Z-bromoethers XIV are produced. 

Under relatively forceful conditions, the rearrangement of l-bromo-7,7-dimethylbicy-clo[2.2.1]heptan-2-one with 2 M aqueous potassium hydroxide at 155 °C gave 5,5-dimethylbi-cyclo[2.1, l]hexane-l-carboxylic acid (2) in 79% yield.55... 

The stabilization of the intermediate as a carhenium - oxonium ion in the diazotization of P-amino alcohols (Tiffeneau-Demjanov rearrangement) is responsible for the formation of 4-bromo-5,5-dimethylbicyclo[2.1.1]hexane-l-carbaldehyde (30) in the reaction of l-amino-4-bromo-7,7-dimethylbicyclo[2.2.1]heptan-2-ol with nitric acid.96... 

A. AMMONIUM [(1 R)-(ENDO, / /V77)]-3-BROMO-l,7-DIMETHYL-2-OXOBICYCLO[2.2.1]HEPTANE-7-METHANESULFONATE [AMMONIUM (+ )589-a-BROMOCAMPHOR-n-SULFONATE]... 

NBFjOsWCmH, Tungsten(l +) pentacar-bonyl-[(diethylamino)methylidyne]-tetrafluoroborate( 1 -), 26 40 NBr04SCraHls, Bicyclo(2.2.l)heptane-7-methanesulfonate, 3-bromo-l, 7-di-methyl-2-oxo-... 

In the early 1970 s, the American Chemical Society authorized an alternative system for naming fully fluorinated compounds or groups in which the symbol F conveys the sense of perfluoro . This system, which has its roots in phi-nomenclature (e.g., (/(-heptane is 1) proposed in the 1940s, has not been used widely enough to warrant adopting it in this book. According to -nomenclature, for example, 2 is F-ncopcntanc, 3 is F-propene, 4 is F-pro-panal, 5 is bromo-F-benzene, and 6 is ethyl F-ethyl ether. 

Heptane 1-(4-Bromo-phcnyl)-7-chloro-dodecafluoro-1-oxo-E10b, 437 (1 -> CO-Ar)... 

Penam p-Lactamase Inhibitors. Penam is the trivial name of 4-thia-l-azabicyclo[3.2.0]heptane. The report that 6-/3-bromopenicillanic acid, [2(5)-(2or. 5 . 6/8)]-6-bromo-3,3-dimethyl-7-oxo-4-thia-l-azabicyclo [3.2.0]lieptane-2-carboxylic acid, (R = Br, R1 = H. R = R1 = CHi) is a potent inhibitor led to intense study both of this compound and analogues. The microbiology profile of 6-/3-bromopenicillanic acid has been reported and the compound has progressed to clinical trials. Mechanistic studies have demonstrated that the dihydrothiazine derivative is responsible for inactivation of /3-lactamases. 

Method D (equation 37) is neither a convenient nor an effective way to generate 3a. After heating bis[bromo(trimethylsilyl)methyl]mercury for 7 days at 160 °C with cyclohexene and diphenylmercury, 7-trimethylsilylbicyclo[4.1.0]heptane was obtained in a yield of only 9%, accompanied by a trace of the carbene dimers (cis- and trans-bis(trimethylsilyl)ethene) and a large amount of starting material75. 

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