Hepcidin antimicrobial peptide

Chang, W. T., Panb, C. Y., Rajanbabu, V., Cheng, C. W., and Chen, J. Y. (2011). Tilapia (Oreochromis mossambicus) antimicrobial peptide, hepcidin 1-5, shows antitumor activity in cancer cells. Peptides 32,342-352. 

Douglas, S. E., Gallant, J. W., Liebscher, R. S., Dacanay, A., and Tsoi, S. . M. (2003). Identification and expression analysis of hepcidin-like antimicrobial peptides in bony fish. Dev. Comp. Immunol. 27, 589-601. 

Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O. A new mouse fiver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001 276 7811-9. 

Park CH, Valore EV, Waring AJ, and Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. Journal of Biological Chemistry 276 7806-7810. 

VERGA FALZACAPPA MV, MUCKENTHALER MU. Hepcidin iron-hormone and antimicrobial peptide. Gene 2005 Dec 30 364 37 4. 

SHIKE H, LAUTH X, WESTERMAN ME, OSTLAND VE, CARLBERG JM, VAN OLST JC, et ol. Bass hepcidin is a novel antimicrobial peptide indnced by bacterial challenge. Eur J Biochem 2002 Apr 269(8) 2232-7. 

SHIKE H, SHIMIZU c, LAUTH X, BURNS JC. Organization and expression analysis of the zebrafish hepcidin gene, an antimicrobial peptide gene conserved among vertebrates. Dev Comp Immunol 2004 Jun 28(7-8) 747-54. 

WANG YD, KUNG cw, CHEN JY. Antiviral activity by fish antimicrobial peptides of epinecidin-1 and hepcidin 1-5 against nervous necrosis virus in medaka. Peptides 2010 Jun 31(6) 1026-33. 

WANG YD, KUNG cw, CHI SC, CHEN JY. Inactivation of nervous necrosis virus infecting grouper (Epinephelus coioides) by epinecidin-1 and hepcidin 1-5 antimicrobial peptides, and downregulation of Mx2 and Mx3 gene expressions. Fish Shellfish Immunol 2010 Jan 28(l) 113-20. 

Finally, the hairpin-like peptides, hepcidins, isolated from human urine and liver [120], and from the gill of hybrid striped bass [121], are more complex, with eight cysteine residues forming four disulphide bridges. They form an unusual distorted P-sheet. Interestingly, besides their antimicrobial activity, hepcidins are the principal hormonal-regulators of iron homeostasis in humans [124]. 

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