Hepatobiliary Tumors

CK17 +/-, CDX-2 +/-, CDS +/-, -f (in tumors from extrahepatic bile ducts), CK20 — (in tumors from inrahepatic bile ducts), Vimentin —/+, AFP -, CK5/6 - 

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Kahn T (2000) Value of CT and MRI in malignant hepatobiliary tumors. Zentralbl Chir 125 610-615... 

Haddad FF, Chapman WC, Wright JK, et al (1998) Clinical experience with cryosurgery for advanced hepatobiliary tumors. J Surg Res 75 104-108 Henn AR, Levine EA, McNulty W, et al (2003) Percutaneous radiofrequency ablation of hepatic metastases for symptomatic relief of neuroendocrine syndromes. AJR Am J Roentgenol 181 1005-1010 Hughes KS, Simon R, Songhorabodi S, et al (1986) Resection of the liver for colorectal carcinoma metastases a multi-institutional study of patterns of recurrence. Surgery 100 278-284... 

The majority (73%) of hepatobiliary tumors are hepatocellular carcinomas many of them are preceded by hepatitis B virus infection. 

The coordination sphere of Gd(III) is almost identical in the complexes of DTPA and BOPTA (Fig. 13), which have similar stabilities and relaxivities (321). By introducing a butylbenzyl group into DTPA, hepatobiliary specificity can be achieved, giving rise to a twofold enhancement of liver tumors in vivo (322). 

The use of 5-FU in combination with radiotherapy has shown improved survival in various malignancies including unresectable pancreatic cancer, resectable pancreatic cancer, Dukes B2 and C rectal cancer, esophageal cancer, and hepatobiliary cancer (Table 2). Similarly, 5-FU with concurrent radiation has also been used for organ preservation in different tumors involving bladder cancer, anal cancer, and laryngeal cancer (Table 3). 

In spite of these promising results, the tumor uptake of 9°Y-SU015 is still relatively low (around 1.5% ID/g at 24 h post injection). The biodistribution data in the c-neu Oncomouse model also show that a small part of 9°Y-SU015 is excreted via the hepatobiliary route. The radioactivity levels in blood, kidney, and liver are relatively high, which makes 9°Y-SU015 less than ideal as a new therapeutic radiopharmaceutical for the treatment of solid tumors. 

Despite its ubiquitous distribution, serum NTP activities appear to reflect hepatobiliary disease with considerable specificity. NTP is increased threefold to sixfold in those hepatobiliary diseases in which there is interference with the secretion of the bile. This may be due to extrahepatic causes (a stone or tumor occluding the bile duct), or it may arise from intrahepatic conditions, such as cholestasis caused by chlorpromazine, malignant infiltration of the liver, or bihary cirrhosis. When parenchymal cell damage is predominant, as in infectious hepatitis, serum NTP activity is only moderately elevated. 

Weihing RR, Shintaku IP, Geller SA, Petrovic LM. Hepatobiliary and pancreatic mucinous cystadenocarcinomas with mesenchymal stroma analysis of estrogen receptors/progesterone receptors and expression of tumor-associated antigens. Mod Pathol. 1997 10 372-379. 

Yanase M, Ikeda LT, Ogata I, et al. Primary smooth muscle tumor of the liver encasing hepatobiliary cystadenoma without mesenchymal stroma. Am Surg Pathol. 1999 23 854-859. 

The liver and spleen can be studied with Tc-labeled sulfur colloid. Space-occupying lesions such as cysts, abscesses, hematomas, or tumors can be detected in static images. For hepatobiliary evaluation derivatives of iminodiacetic acid labeled with... 

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