Hepatic Uptake of Organic Cations

By analyzing the uptake into the isolated rat hepatocytes, it has been suggested that organic cations may be classified into two groups as follows  

In contrast, some Type II cations, such as N-(4,4-azo-n-pentyl)-21-deoxy-ajmalinium and rocuronium, have been shown to be transported by rat Oatp 2 [64—66]. Since human OATP2 or OATP8 cannot transport organic cations [53], the molecular mechanism for the uptake of Type II cations (e.g., rocuronium) into isolated human hepatocytes [11] remains to be clarified. Although human OATP-A transports rocuronium, its hepatic expression is minimal [66]. 

---