Hemorrhagic tendency

Hemophilia or other hemorrhagic tendencies Severe liver disease with elevated baseline PT Severe thrombocytopenia (platelet count less than 20,000) Malignant hypertension... 

Absolute contraindications to warfarin include active bleeding, hemorrhagic tendencies, pregnancy, and a history of warfarin-induced skin necrosis. It should be used with great caution in patients with a history of GI bleeding, recent neurosurgery, alcoholic liver disease, severe renal... 

Hemorrhagic tendency may be manifested by hematuria, skin petechiae, hemorrhage into or from a wound or ulcerating lesion, or petechial and purpuric hemorrhages throughout the body. 

In chronic benzene intoxication, mild poisoning produces headache, dizziness, nausea, stomach pain, anorexia, and hypothermia. In severe cases, pale skin, weakness, blurred vision, and dyspnea occur on exertion. Hemorrhagic tendencies include petechia, easy bruising, and bleeding gums. Bone marrow depression produces a decrease in circulating peripheral erythrocytes and leucocytes (101). Fatalities from chronic exposure show at autopsy severe bone marrow aplasia, and necrosis or fatty degeneration of the heart, fiver, and adrenals (125). 

The mechanism of action of mithramycin (Mithracin) is similar to that of dactinomycin. It is used in patients with advanced disseminated tumors of the testis and for the treatment of hypercalcemia associated with cancer. Mithramycin may cause gastrointestinal injury, bone marrow depression, hepatic and renal damage, and hemorrhagic tendency (see Chapter 62). 

Contraindications Allergy to heparin uncontrolled bleeding Allergy to heparin. Awid in patients with CrQ of < 30 ml/ min. Use in caution in patients with low body weights. Pregnancy hemorrhagic tendencies... 

The liver manufactures most of the clotting factors (the major exception being von Willebrand factor) and bile salts that are essential for absorption of vitamin K. The liver also clears activated clotting factors from the circulation. Thus chronic liver disease is associated with both a hemorrhagic tendency and a hypercoagulable state. ... 

Ray NR, Ray AK. 1973. Studies on some blood pictures in relation to hemorrhagic tendency during selenium toxicity. Ind J Physiol Allied Sci 27 152-154. 

When cadmium exposure continues past the onset of early kidney damage (manifested as proteinuria), chronic nephrotoxicity may occur (Meridian Research, Inc. 1989 Roth Associates, Inc. 1989). Uremia, which is the loss of the glomerulus ability to adequately filter blood, may result. This condition leads to severe disturbance of electrolyte concentrations, which may result in various clinical complications including atherosclerosis, hypertension, pericarditis, anemia, hemorrhagic tendencies, deficient cellular immunity, bone changes, and other problems. Progression of the disease may require dialysis or a kidney transplant. 

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