Primaquine-sensitive hemolytic anemia

Bll. Beutler, E., Drug-induced hemolytic anemia (Primaquine sensitivity). In The Metabolic Basis of Inherited Disease (J. B. Stanbury, J. B. Wyngaarden, and D. S. Fredrickson, eds.), pp, 1031-1067. McGraw-Hill, New York, 1960. 

The answers are 484-k 485-j. (tlardman, pp 1061-1062, 1682-1685.) Sulfonamides can cause acute hemolytic anemia. In some patients it mayr be related to a sensitization phenomenon, and in other patients the hemolysis is due to a glucose-6-phosphate dehydrogenase deficiency Sulfamethoxazole alone or in combination with trimethoprim is used to treat UTls. The sulfonamide sulfasalazine is employed in the treatment of ulcerative colitis. Daps one, a drug that is used in the treatment of leprosy, and primaquine, an anti mala rial agent, can produce hemolysis, particularly in patients with a glucose-6-phosphate dehydrogenase deficiency. 

Hematologic effects Cases of hemolytic anemia of the primaquine-sensitivity type have been induced by nitrofurantoin. 

Hemolytic anemia of the primaquine sensitivity type has been induced by nitrofurantoin. The hemolysis appears to be linked to a glucose 6-phosphate dehydrogenase (G-6-PD) deficiency in the red blood cells of affected patients. 

Fig. 3-19. Some chemical pathways related to primaquine-sensitive hemolytic anemia. 1 Glucose-6-phosphate dehydrogensase 2 Lac-tonase 3 6-Phosphogluconic dehydrogenase 4 Glutathione reductase...

---